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Through the multicenter RISE Pediatric Medication Study, investigators hope to learn whether treatments used for diabetes can slow the change from prediabetes to diabetes, or slow the progression of diabetes in youth recently diagnosed with type 2 diabetes or prediabetes. Researchers currently believe that the best time to slow or prevent diabetes is in its earliest stages. While the primary goal is to determine if aggressive insulin therapy can lead to sustained recovery of beta-cell function, researchers will also assess durability of glucose tolerance following withdrawal of therapy and whether biomarkers can predict parameters of beta-cell function, insulin sensitivity, and glucose tolerance, and the response to an intervention.
Subject to certain exclusion criteria, the study is accepting children of both genders, ages 10 through 19, who have been diagnosed with early type-2 diabetes or prediabetes.
Boys and Girls: Ages 10-19
The study has 2 parts: a screening phase and a treatment phase. Screening includes an examination, an oral glucose tolerance test and a medication “run-in” period. Those who pass the screening phase will be randomized into one of the following treatment regimens: either oral metformin alone for 12 months or injections of insulin glargine for 3 months followed by metformin for up to 9 months.
Duration: Up to 21 months
National Institute of Diabetes and Digestive and Kidney Diseases
National Institutes of Health
Silva A. Arslanian, MD
For information or to enroll, please contact:
The RISE Study Team
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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