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Bone marrow is a soft tissue inside the body's bones. Within this tissue are special cells called stem cells.
Your body uses stem cells to make:
All of these blood cells are vital to your health.
When bone marrow doesn't make enough of these cells, doctors call it bone marrow failure. Bone marrow failure might also produce damaged cells.
Bone marrow failure disorders are a group of conditions. In other words, there is more than one type of bone marrow failure disorder.
Some types are genetic, meaning parents pass them to their children through genes. Also known as inherited bone marrow failure syndromes, they are more common in children.
Acquired bone marrow failure disorders come from:
Bone marrow failure disorders are rare diseases.
Our experts at UPMC Children's Hospital of Pittsburgh treat a range of genetic and acquired bone marrow failure disorders:
Children with bone marrow failure disorders are at risk of certain cancers:
Since there are many types of bone marrow failure disorders, symptoms vary.
Some symptoms your child might have include:
Talk with your doctor if you notice changes in your child or have concerns about something you see.
Bone marrow failure disorders are rare.
To make a diagnosis, doctors gather data and use certain tests such as:
Talk with your doctor about any new symptoms or changes you've noticed in your child. You know your child best and anything you share helps.
How doctors treat your child's bone marrow failure disorder depends on the type your child has.
Our experts in the Bone Marrow Failure Disorders Program work with you and your family to manage your child's care.
Treatments for bone marrow failure might include:
Your care team will talk with you about which treatments are right for your child.
You can count on our doctors to partner with you and your family in managing your child's illness.
Doctors in the Bone Marrow Failure Disorders Program work with experts in the Blood and Marrow Transplantation and Cellular Therapies Program. Our team approach means your child will get care from the region's top experts in treating bone marrow failure disorders.
Our membership in the North American Pediatric Aplastic Anemia Consortium gives us access to clinical trials with the newest tests and treatments.
When you come for your first visit, you will:
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Support the hospital by making a donation online, joining our Heroes in Healing monthly donor program, or visiting our site to learn about the other ways you can give back.