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The goal of this multi-center study of the Children’s Oncology Group is to determine if a drug called selumetinib works as well as the standard treatment and with fewer side effects for young people with a low-grade glioma. Selumetinib is a drug that works by blocking a protein that lets cancer cells grow without stopping.
Subject to certain exclusion criteria, this study is enrolling patients ages 2 through 21 years diagnosed with a low-grade glioma. Males and Females: Ages 2 through 21 years
Participants will be randomly selected to receive therapy with selumetinib taken orally as a capsule or the standard treatment, which uses a combination of the drugs carboplatin and vincristine given intravenously. Therapy with selumetinib takes about 27 months to complete and the standard therapy takes about 15 months to complete for most participants. Visits: Number of visits will vary based on study arm and the participant’s response to protocol. Duration: In addition to the treatment phase, participants will complete research tests for about 5 years after they enter this study.
Children’s Oncology Group (ACNS1833) National Cancer Institute
Study Description at the National Institutes of Health Cancer and Blood Disorder Research
James Felker, MD
For more information about the study or enrollment, please contact the UPMC Children’s Hospital of Pittsburgh Neuro-Oncology team, at: chphoneuro-onc@upmc.edu
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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