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For more information about research, please call our main office at 412-692-6438.
Children's Hospital is ranked One of America's Best Children's Hospitals.
The purpose of the study is to evaluate the efficacy and safety of the drug prasugrel for the reduction of acute chest syndrome, a severe form of vaso-occlusive crisis (VOC), in children, adolescents, and teens with sickle cell disease. The study will also investigate reduction in daily pain in children who have sickle cell disease.
Subject to certain exclusion criteria, the study is accepting participants of both genders, ages of 2 through 17, who have sickle cell disease and who have experienced 2 or more sickle cell-related pain episodes within the past year.
Males: 2 to 17 years old
Females: 2 to 17 years old
Following initial screening, participants will be placed into one of two study groups: one that takes the study drug and one that takes a placebo. The drug and placebo are in tablet form, taken orally each day, and most dosages will be taken at home. For participants older than 4, an electronic diary will be provided for recording daily pain, use of medications and any difficulties conducting normal activities. Periodic office visits will be required for examinations and blood samples.
Duration: 9 months to 2 years
Eli Lilly and Company
Study Description at National Institutes of Health
Debra Cohen, MD
For information about the study or enrollment, please contact:
Study Coordinator Angela Martino, BSN, RN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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