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The purpose of this study is to administer the drug Defibrotide in patients with veno-occlusive disease (VOD), a complication that can result from chemotherapy, radiation therapy and other agents used in marrow transplants. VOD is a failure of blood flow through the liver that can create a life-threatening condition requiring immediate treatment. VOD can result in jaundice, liver dysfunction, weight gain and swelling of the abdomen. Defibrotide is an experimental drug that is not approved by the Food and Drug Administration, however it is believed to prevent the formation of blood clots when given by vein every 6 hours, usually for 14 days.
Children and young adults who have been diagnosed with veno-occlusive disease (VOD) will be asked to be participants in this study.
Boys: All ages
Girls: All ages
Participants will undergo a physical examination including blood work and an abdominal ultrasound. Defibrotide will be administered intravenously every 6 hours, usually for 14 days. It is possible that additional courses of this drug may be administered.
Visits: Requires hospitalization
Duration: 2 weeks
Rakesh Goyal, MD
To get started, please contact:
Rakesh Goyal, MD
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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