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For more information about research, please call our main office at 412-692-6438.
Children's Hospital is ranked One of America's Best Children's Hospitals.
Oral vaccination can provide effective protection against infection. However, in low-income countries where oral vaccines are most vital, they have been found to be largely ineffective. Our lab seeks to identify the factors important for effective oral vaccination.
The effectiveness of vaccination depends on the development of long-lived T and B cells. Critically, for effective protection, these cells need to reside at the mucosal surfaces they aim to protect. Unfortunately the molecular and biochemical signatures necessary for survival and differentiation at these sites are unknown and therefore are a main focus of the lab.
The failure of oral vaccination in low-income countries has been associated with a chronic autoinflammatory enteropathy. We recently developed a model of enteric infection with Yersinia pseudotuberculosis that leads to chronic damage to the gut-associated lymphatics and lymph nodes, ultimately reducing the effectiveness of oral vaccination. We are planning to investigate the mechanisms of this defect and their relationship to human disease.
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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