Infectious Diseases Research

The Division of Pediatric Infectious Diseases is comprised of faculty with expertise in basic, translational and clinical research.

The focus of basic research in the division is on the immunity and pathogenesis of pulmonary infections such as M. tuberculosis and human metapneumovirus. Translational research studies include the treatment of congenital cytomegalovirus (CMV) and neonatal herpes simplex virus (HSV) infections, epidemiology of lyme disease, epidemiology of respiratory viruses, multi-drug resistant bacteria, treatment of acute otitis media, pathogenesis and treatment of urinary tract infections and infections in organ transplant recipients.

Clinical studies are conducted through the Infectious Disease Clinical Research Unit (CRU) and include studies that are regional, national and international in scope. The CRU itself has evolved considerably since its earliest days as the Pittsburgh Vaccine Center and is current involved in investigator-initiated studies funded by the National Institutes of Health and Centers for Diseases Control and Prevention as well as several pharmaceutical sponsored studies.

Current clinical studies by the Division of Pediatric Infectious Diseases involve research related to influenza vaccine efficacy, congenital CMV and neonatal HSV, invasive pneumococcal infections, and multi-drug resistant pathogens to name just a few.

Division scientists maintain close ties to Children’s services that care for patients undergoing both organ (heart, heart-lung, liver, small bowel and kidney) and bone marrow transplantation. In addition, the division provides exceptional care to children exposed to or affected by the human immunodeficiency virus (HIV). The University of Pittsburgh is an extremely collegial institution, and PID fellows have the opportunity to conduct research with investigators in the departments of Immunology Medicine, Microbiology and Molecular Genetics, as well as the University of Pittsburgh School of Public Health.


Clinical Trials

Acute Gastroenteritis (AGE) and Acute Respiratory Illness (ARI) in Children

Enhanced Active Surveillance of Pediatric Infectious Disease and Vaccine by the New Vaccine Surveillance Network

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Candidiasis Treatment with Anidulafungin

A Study to Assess the Pharmacokinetics, Safety and Efficacy of Anidulafungin When Used to Treat Children with Invasive Candidiasis, Including Candidemia

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Candidiasis Treatment with Micafungin in Neonates – Phase III

A Study to Compare the Efficacy and Safety of Micafungin Versus Amphotericin B Deoxycholate for the Treatment of Neonatal Candidiasis

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Clostridium Difficile-Associated Diarrhea Treatment with Fidaxomicin – Phase IIa

Study to Determine the Safety, Tolerability and Pharmacokinetics of Fidaxomicin Oral Suspension or Tablets in Pediatric Subjects with Clostridium Difficile-associated Diarrhea (CDAD)

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Influenza Treatment in Immunocompromised Patients – Phase IV

Treatment of Immunocompromised Patients with Conventional and High Dose Oseltamivir

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Influenza Treatment with Zanamivir for Hospitalized Patients

Study to Evaluate the Safety and Tolerability of Intravenous Zanamivir in the Treatment of Hospitalized Adult, Adolescent and Pediatric Subjects with Confirmed Influenza Infection

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Respiratory Fungal Infection Treatment with Voriconazole – Phase II

Voriconazole as Therapy for Treatment of Invasive Aspergillosis and Molds

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