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What is a Liver Transplant?
A liver transplantation is an operation performed to replace a diseased liver with a healthy one from another person. An entire liver may be transplanted, or just a section. The liver may come from an organ donor, or from a family member who is willing to donate a part of his/her liver and is a suitable candidate to donate.
Why is a Liver Transplant Recommended?
Liver transplantation is recommended for children who have serious liver dysfunction and will not be able to live without having the liver replaced. The most common liver disease in children for which transplants are done is biliary atresia. Other liver diseases may include Alagille's Syndrome, alpha-1-antitrypsin deficiency, Wilson's disease, hepatitis, and hemochromatosis.
Where do Transplanted Livers Come From?
The majority of livers that are transplanted come from deceased organ donors. Organ donors are adults or children who have become critically ill (often due to an accidental injury) and will not live as a result of their illness or injury. If the doctor is an adult, he/she may have agreed to be an organ donor before becoming ill. Parents or spouses can also agree to donate a relative's organs. Donors can come from any part of the United States. This type of transplant is called a cadaveric transplant.
A child receiving a liver transplant may either get a whole liver, or a segment of one. If an adult liver is available and is an appropriate match for two children on the waiting list, the donor liver can be divided into two segments and each part is transplanted.
Living family members may also be able to donate a section of their liver. This type of transplant is called a living-related transplant. Children receiving a partial liver seem to do as well as those who receive a whole liver. Relatives who donate a portion of their liver can live healthy lives with the segment that remains.
How are Transplanted Livers Allocated?
The United Network for Organ Sharing (UNOS) is responsible for transplant organ distribution in the United States. UNOS oversees the allocation of many different types of transplants, including liver, kidney, pancreas, heart, lung, and cornea.
UNOS receives data from hospitals and medical centers throughout the country regarding adults and children who require a liver transplantation. The medical team that currently follows your child is responsible for sending the data to UNOS, and updating them as your child's condition changes.
Criteria have been developed to ensure that all people are on the waiting list are judged fairly as to the severity of their illness and the urgency of receiving a transplant. Once UNOS receives the data from local hospitals, people waiting for a transplant are placed on a waiting list and given a "status" code. The people in most urgent need of a transplant are placed highest on the status list and are given first priority when a donor liver becomes available.
When a donor organ becomes available, a computer searches all the people on the waiting list for a liver and sets aside those who are not good matches for the available liver. A new list is made from the remaining candidates. The person at the top of the specialized list is considered for the transplant. If he/she is not a good candidate, for whatever reason, the next person is considered,and so forth. Some reasons that people lower on the list might be considered before a person at the top include the size of the donor organ and the geographical distance between the donor and the recipient.
How is My Child Placed on the Waiting List for a New Liver?
An extensive evaluation must be completed before your child can be placed on the transplant list.Testing includes
Tests are done to gather information that will help determine how urgent it is that your child is placed on the transplant list, as well as ensure the child receives a donor liver that is a good match. These tests include those to analyze the general health of the body, including the child's heart, lung, and kidney function, the child's nutritional status, and the presence of infection. Blood tests will help improve the chances that the donor liver will not be rejected. These tests may include:
Other blood tests will help improve the chances that the donor organ will not be rejected. They may include:
How Long Will it Take to Get a New Liver?
There is no definite answer to this question. Sometimes, children wait only a few days or weeks before receiving a donor organ. If no living-donor is available, it may take months or years on the waiting list before a suitable donor organ is available. During this time, your child will have close follow-up with his/her physician and the transplant team. Various support groups are also available to assist you during this waiting time.
How Are We Notified When a Liver is Available?
Each transplant team has their own specific guidelines regarding waiting on the transplant list and being notified when a donor organ is available. In most instances, you will be notified by phone or pager that an organ is available. You will be told to come to the hospital immediately so your child can be prepared for the transplant.
What is Involved in Liver Transplant Surgery?
Once a liver becomes available to your child, you and your child will be immediately called to the hospital. The call can occur at any time, so you should always be prepared to go to the hospital, if needed. Once at the hospital, the child will have some more final blood work and tests to confirm the match of the liver.
The child will then go to the operating room. The liver transplantation surgery may require several hours, but will vary greatly depending on each individual case. During the surgery, a member of the transplant team will keep you informed on the progress of the transplantation.
The group of specialists involved in the care of children who are undergoing a liver transplantation procedure is often referred to as the "transplant team." Each individual works together to provide the best chance for a successful transplant. The liver transplant teams consists of:
After the surgery, your child will go to the intensive care unit (ICU) to me monitored closely. The length of time your child will spend in the ICU will vary based on your child's unique condition. After your child is stable, he/she will be sent to the special unit in the hospital that cares for liver transplant patients. Your child will continue to be monitored closely. You will be educated on all aspects of caring for your child during this time. This will include information about medications, activity, follow-up, diet, and any other specific instructions from your child's transplant team.
What is Liver Rejection?
Rejection is a normal reaction of the body to a foreign object. When a new liver is placed in a person's body, the body sees the transplanted organ as a threat and tries to attack it. The immune system makes antibodies to try to kill the new organ, not realizing that the transplanted liver is beneficial. To allow the organ to successfully live in a new body, medications must be given to trick the immune system into accepting the transplant and not thinking it is a foreign object.
What Are the Symptoms of Liver Rejection?
The following are the most common signs and symptoms of rejection. However, each child may experience symptoms differently. Symptoms may include:
Your child's transplant team will instruct you on whom to call immediately if any of these symptoms occur.
What is Done to Prevent Liver Rejection?
Medications must be given for the rest of the child's life to fight rejection. Each child is unique, and each transplant team has preferences for different medications. Some of the anti-rejection medications most commonly used include the following:
The doses of these medications may change frequently, depending upon your child's response. Because anti-rejection medications affect the immune system, children who receive a transplant will be at higher risk for infections. A balance must be maintained between preventing rejection and making your child very susceptible to infection. Blood tests to measure the amount of medication in the body are done periodically to make sure your child does not get too much or too little of the medications. White blood cells are also an important indicator of how much medication your child needs.
What about Infection?
The risk of infection is especially great in the first few months after the liver transplantation because higher doses of anti-rejection medications are given during this time. Your child will most likely need to take medications to prevent other infections from occurring. Some of the infections your child will especially susceptible to include oral yeast infection (thrush), herpes, and respiratory viruses.
Living with a transplant is a life-long process. Medications must be given that trick the immune system so it will not attack the transplanted organ. Other medications must be given to prevent side effects of the anti-rejection medications such as, infection. Frequent visits to and contact with the transplant team are essential. When the child becomes old enough, he/she will need to learn about anti-rejection medications, what they can do, the signs on rejection, and everything else the parents have learned so he/she can eventually care for himself/herself independently.
Every child is unique and every transplant is different. Results continually improve as physicians and scientists learn more about how the body deals with transplanted organs and search for ways to improve transplantation.
Learn more about the Liver Transplant Procedure.
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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