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To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
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For more information about research, please call our main office at 412-692-6438.
Ranked #8 Nationally by U.S. News & World Report.
CPROM researchers – both clinicians and medical scientists – collaborate on investigations to provide a comprehensive understanding of the relationship between metabolism and obesity, ultimately supporting our pursuit of the most effective patient programs and therapies. Some of our laboratory investigations are listed here, and you can also learn more about our patient-oriented research studies.
Adipocytes-derived Hormones and Cardiovascular Function Principal Investigator: Thiago Bruder do Nascimento, PhD Based on earlier findings that the endothelial leptin receptor is essential for vascular health, this research explores which mechanisms within adipose tissue contribute to cardiovascular health and disease.
FOXO1 in Beta-Cell Compensation Principal Investigator: H. Henry Dong, PhD This National Institutes of Health sponsored project is to characterize genetic factors that are responsible for coupling beta-cell compensation with nutrient signals to understand the underlying mechanism of beta-cell failure in diabetes.
Reprograming of Pancreatic Alpha-Cells Into Functioning Insulin-Producing Cells as a Therapy for Type 2 Diabetes Principal Investigator: Mohamed Saleh, MD, Senior Pediatric Endocrine Fellow Mentor: George Gittes, MD, Professor, Department of Surgery, University of Pittsburgh School of Medicine This project proposes to infuse adeno-associated virus carrying Pdx1 and MafA expression cassettes through the pancreatic duct and convert α-cells into insulin-producing cells in the animal model. Besides potentially restoring insulin secretion capacity, researchers believe that by specifically targeting α-cells, this strategy might correct the hyperglucagonemia and ameliorate hyperglycemia.
Nitrite Modulation of Hypertension, Platelet Activation, Endothelial and Mitochondrial Function Principal Investigator: Kara Hughan, MD Mentor: Mark Gladwin, MD, Professor and Chair, Department of Medicine, University of Pittsburgh School of Medicine This program aims to examine the effects of chronic oral nitrite therapy on blood pressure, endothelial function and insulin sensitivity and whether it modulates mitochondrial energetics, oxidative stress and redox signaling in platelets and skeletal muscle.
Cystic Fibrosis Foundation EnVision Program Principal Investigator: Kara Hughan, MD This program studies the relationship of glucose abnormalities and liver stiffness in patients with cystic fibrosis. Investigators will observe correlations between liver stiffness using transient elastography and glucose abnormalities using oral glucose tolerance tests in individuals ages 6 to 25 with cystic fibrosis.
University of Pittsburgh and Bayer HealthCare LLC Master Collaboration Agreement – Electronic Approach to PCOS Phenotyping Principal Investigator: Kara Hughan, MD This study aims to define an electronic health record (EHR) phenotype that can be queried in female patients with polycystic ovary syndrome (PCOS) who are being seen in UPMC facilities. A subset will be manually validated according to one or more of the three diagnostic criteria for PCOS.
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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Interested in giving to Children's Hospital? Support the hospital by making a donation online, joining our Heroes in Healing monthly donor program, or visiting our site to learn about the other ways you can give back.