The following is a summary of just some of the published articles by members of the Center for Pediatric Research in Obesity and Metabolism.

CCR5 Antagonist Treatment Inhibits Vascular Injury by Regulating NADPH Oxidase 1
Singh S, Bruder-Nascimento A, Belin de Chantemele E, Bruder-Nascimento T
Biochemical Pharmacology
2022 Jan

Adipose Tissue in the Cardiovascular Homeostasis and Disease
Butcher JT, Davel AP, Bruder-Nascimento T
Frontiers in Pharmacology
2021 Nov 24

Reduced Endothelial Leptin Signaling Increases Vascular Adrenergic Reactivity in a Mouse Model of Congenital Generalized Lipodystrophy
B. Bruder-Nascimento T, Kress TC, Pearson M, Chen W, Kennard S, Belin de Chantemele EB
International Journal of Molecular Science
2021 Sep 30

Real-World Treatment Escalation from Metformin Monotherapy in Youth-Onset Type 2 Diabetes Mellitus: A Retrospective Cohort Study
Vajravelu ME, Hitt TA, Amaral S, Katz LEL, Lee JM, Kelly A
Pediatric Diabetes 
2021 Sep

Angiotensin-II Activates Vascular Inflammasome and Induces Vascular Damage
Cau SB, Bruder-Nascimento A, Silva MB, Ramalho FNZ, Mestriner F, Alves-Lopes R, Ferreira N, Tostes RC, Bruder-Nascimento T
Vascular Pharmacology
2021 Aug

Sex-Based Differences in Screening and Recognition of Prediabetes and Type 2 Diabetes in Pediatric Primary Care
Vajravelu ME, Lee JM, Amaral S, Kelly A
Pediatric Obesity
2021 Feb

Gut Microbiome Profile after Pancreatectomy in Infants with Congenital Hyperinsulinism
Vajravelu ME, Lee JJ, Mitteer L, Zemel BS, Bittinger K, De Leon DD
2021 Jan 1

HIV Protease Inhibitor Ritonavir Impairs Endothelial Function Via Reduction in Adipose Mass and Endothelial Leptin Receptor-Dependent Increases in NADPH Oxidase 1 (Nox1), C-C Chemokine Receptor Type 5 (CCR5), and Inflammation
Bruder-Nascimento T, Kress T, Kennard S, Belin de Chantemele, EJ.
Journal of the American Heart Association
2020 Oct 6

Association between Prediabetes Diagnosis and Body Mass Index Trajectory of Overweight and Obese Adolescents
Vajravelu ME, Lee JM, Shah R, Shults J, Amaral S, Kelly A
Pediatric Diabetes
2020 Aug

Pharmacokinetic and Pharmacodynamic Profile of the Sodium-glucose Co-transporter-2 Inhibitor Empagliflozin in Young People With Type 2 Diabetes: A Randomized Trial
Laffel LMB, Tamborlane WV, Yver A, Simons G, Wu J, Nock V, Hobson D, Hughan KS, Kaspers S, Marquard J
Diabetic Medicine
2018 Apr 14

Impaired Lipolysis, Diminished Fat oxidation and Metabolic Inflexibility in Obese Girls with Polycystic Ovary Syndrome
Kim JY, Tfayli H, Michaliszyn S, Arslanian S
The Journal of Clinical Endocrinology & Metabolism
2018 Feb

Increased Lipolysis, Diminished Adipose Tissue Insulin Sensitivity and Impaired β-cell Function Relative to Adipose Tissue Insulin Sensitivity in Obese Youth with Impaired Glucose Tolerance (IGT)
Kim JY, Nasr A, Tfayli H, Bacha F, Michaliszyn S, Arslanian S
2017 Dec

Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate
Hughan KS, Wendell SG, Delmastro-Greenwood M, Helbling N, Corey C, Bellavia L, Potti G, Grimes G, Goodpaster B, Kim-Shapiro DB, Shiva S, Freeman BA, Gladwin MT
2017 Jul 24

Response to Letter “Pediatric Obesity – Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline.”
Styne DM, Arslanian S, Connor EL, Farooqi IS, Murad H, Silverstein, JH, Yanovski JA
The Journal of Clinical Endocrinology & Metabolism
2017 Jun 6

Pediatric Obesity – Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline
Styne DM, Arslanian S, Connor EL, Farooqi IS, Murad H, Silverstein, JH, Yanovski JA
The Journal of Clinical Endocrinology & Metabolism
2017 Jan 31

Adiponectin, Insulin Sensitivity, β-cell function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY
TODAY Study Group: Arslanian S, El Ghormli L, Bacha F, Caprio S, Goland R, Haymond M, Levitsky L, Nadeau K, White N, Willi S
Diabetes Care
2017 Jan

The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test Heralds Biomarkers of Type 2 Diabetes Risk in Obese Youth
Kim JY, Michaliszyn SF, Nasr A, Lee SJ, Tfayli H, Hannon T, Hughan KS, Bacha F, Arslanian S
Diabetes Care
2016 Aug

FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice
Zhang T, Kim DH, Xiao X, Lee S, Gong Z, Muzumdar R, Calabuig-Navarro V, Yamauchi J, Harashima H, Wang R, Bottino R, Alvarez-Perez JC, Garcia-Ocaña A, Gittes G, Dong HH
2016 Mar

SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction
Lai YC, Tabima DM, Dube JJ, Hughan KS, Vanderpool RR, Goncharov DA, St Croix CM, Garcia-Ocaña A, Goncharova EA, Tofovic SP, Mora AL, Gladwin MT
2016 Feb 23

Early Biomarkers of Subclinical Atherosclerosis in Obese Adolescent Girls with Polycystic Ovary Syndrome
Hughan KS, Tfayli H, Warren-Ulanch JG, Barinas-Mitchell E, Arslanian S
Journal of Pediatrics
2016 Jan