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The following is a summary of just some of the published articles by members of the Center for Pediatric Research in Obesity and Metabolism.
Pharmacokinetic and Pharmacodynamic Profile of the Sodium-glucose Co-transporter-2 Inhibitor Empagliflozin in Young People With Type 2 Diabetes: A Randomized Trial Laffel LMB, Tamborlane WV, Yver A, Simons G, Wu J, Nock V, Hobson D, Hughan KS, Kaspers S, Marquard J Diabetic Medicine 2018 Apr 14
Impaired Lipolysis, Diminished Fat oxidation and Metabolic Inflexibility in Obese Girls with Polycystic Ovary Syndrome Kim JY, Tfayli H, Michaliszyn S, Arslanian S The Journal of Clinical Endocrinology & Metabolism 2018 Feb
Increased Lipolysis, Diminished Adipose Tissue Insulin Sensitivity and Impaired β-cell Function Relative to Adipose Tissue Insulin Sensitivity in Obese Youth with Impaired Glucose Tolerance (IGT) Kim JY, Nasr A, Tfayli H, Bacha F, Michaliszyn S, Arslanian S Diabetes 2017 Dec
Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate Hughan KS, Wendell SG, Delmastro-Greenwood M, Helbling N, Corey C, Bellavia L, Potti G, Grimes G, Goodpaster B, Kim-Shapiro DB, Shiva S, Freeman BA, Gladwin MT Hypertension 2017 Jul 24
Response to Letter “Pediatric Obesity – Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline.” Styne DM, Arslanian S, Connor EL, Farooqi IS, Murad H, Silverstein, JH, Yanovski JA The Journal of Clinical Endocrinology & Metabolism 2017 Jun 6
Pediatric Obesity – Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline Styne DM, Arslanian S, Connor EL, Farooqi IS, Murad H, Silverstein, JH, Yanovski JA The Journal of Clinical Endocrinology & Metabolism 2017 Jan 31
Adiponectin, Insulin Sensitivity, β-cell function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY TODAY Study Group: Arslanian S, El Ghormli L, Bacha F, Caprio S, Goland R, Haymond M, Levitsky L, Nadeau K, White N, Willi S Diabetes Care 2017 Jan
The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test Heralds Biomarkers of Type 2 Diabetes Risk in Obese Youth Kim JY, Michaliszyn SF, Nasr A, Lee SJ, Tfayli H, Hannon T, Hughan KS, Bacha F, Arslanian S Diabetes Care 2016 Aug
FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice Zhang T, Kim DH, Xiao X, Lee S, Gong Z, Muzumdar R, Calabuig-Navarro V, Yamauchi J, Harashima H, Wang R, Bottino R, Alvarez-Perez JC, Garcia-Ocaña A, Gittes G, Dong HH Endocrinology 2016 Mar
SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction Lai YC, Tabima DM, Dube JJ, Hughan KS, Vanderpool RR, Goncharov DA, St Croix CM, Garcia-Ocaña A, Goncharova EA, Tofovic SP, Mora AL, Gladwin MT Circulation 2016 Feb 23
Early Biomarkers of Subclinical Atherosclerosis in Obese Adolescent Girls with Polycystic Ovary Syndrome Hughan KS, Tfayli H, Warren-Ulanch JG, Barinas-Mitchell E, Arslanian S Journal of Pediatrics 2016 Jan
The Changing Face of Diabetes in Youth: Lessons Learned from Studies of Type 2 Diabetes Hannon T, Arslanian S Annals of the New York Academy of Sciences 2015 Oct 8
β-cell Function, Incretin Effect and Incretin Hormones in Obese Youth along the Span of Glucose Tolerance from Normal to Prediabetes to Type 2 Diabetes Michaliszyn S, Mari A, Lee S, Bacha F, Tfayli H, Farchoukh L, Ferrannini E, Arslanian S Diabetes 2014 Nov
Coronary Artery Calcification in Obese Youth: What are the Phenotypic and Metabolic Determinants? Bacha F, Edmundowicz D, Sutton-Tyrell K, Lee S, Tfayli H, Arslanian S Diabetes Care 2014 Sep
Restoring Insulin Secretion (RISE): Design of Studies of β-Cell Preservation in Prediabetes and Early Type 2 Diabetes Across the Life Span RISE Study Group: Nadeau K, Mather K, Arslanian S, Buchanan T, Caprio S, Edelstein S, Ehrmann, D, Savage P, Kahn S Diabetes Care 2014 Mar
Effects of Metformin, Metformin Plus Rosiglitazone, and Metformin Plus Lifestyle on Insulin Sensitivity and β-Cell Function in TODAY TODAY Study Group: Arslanian S, Pyle L, Payan M, Bacha F, Caprio S, Haymond M, Levitsky LL, Goland R, White N, Willi SM Diabetes Care 2013 June 1
β-Cell Lipotoxicity After an Overnight Intravenous Lipid Challenge and Free Fatty Acid Elevation in African American Versus American White Overweight/obese Adolescents Hughan KS, Bonadonna RC, Lee S, Michaliszyn SF, Arslanian SA The Journal of Clinical Endocrinology & Metabolism 2013 May
FoxO6 Integrates Insulin Signaling With Gluconeogenesis in the Liver Kim DH, Perdomo G, Zhang T, Slusher S, Lee S, Phillips BE, Fan Y, Giannoukakis N, Gramignoli R, Strom S, Ringquist S, Dong HH Diabetes 2011 Nov
FoxO1 Mediates Insulin-dependent Regulation of Hepatic VLDL Production in Mice Kamagate A, Qu S, Perdomo G, Su D, Kim DH, Slusher S, Meseck M, Dong HH The Journal of Clinical Investigation 2008 Jun 2
Foxo1 Mediates Insulin Action on apoC-III and Triglyceride Metabolism Altomonte J, Cong L, Harbaran S, Richter A, Xu J, Meseck M, Dong HH The Journal of Clinical Investigation 2004 Nov 15
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UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
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