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The following is a summary of just some of the published articles by members of the Center for Pediatric Research in Obesity and Metabolism.
CCR5 Antagonist Treatment Inhibits Vascular Injury by Regulating NADPH Oxidase 1 Singh S, Bruder-Nascimento A, Belin de Chantemele E, Bruder-Nascimento T Biochemical Pharmacology 2022 Jan Adipose Tissue in the Cardiovascular Homeostasis and Disease Butcher JT, Davel AP, Bruder-Nascimento T Frontiers in Pharmacology 2021 Nov 24 Reduced Endothelial Leptin Signaling Increases Vascular Adrenergic Reactivity in a Mouse Model of Congenital Generalized Lipodystrophy B. Bruder-Nascimento T, Kress TC, Pearson M, Chen W, Kennard S, Belin de Chantemele EB International Journal of Molecular Science 2021 Sep 30 Real-World Treatment Escalation from Metformin Monotherapy in Youth-Onset Type 2 Diabetes Mellitus: A Retrospective Cohort Study Vajravelu ME, Hitt TA, Amaral S, Katz LEL, Lee JM, Kelly A Pediatric Diabetes 2021 Sep Angiotensin-II Activates Vascular Inflammasome and Induces Vascular Damage Cau SB, Bruder-Nascimento A, Silva MB, Ramalho FNZ, Mestriner F, Alves-Lopes R, Ferreira N, Tostes RC, Bruder-Nascimento T Vascular Pharmacology 2021 Aug Sex-Based Differences in Screening and Recognition of Prediabetes and Type 2 Diabetes in Pediatric Primary Care Vajravelu ME, Lee JM, Amaral S, Kelly A Pediatric Obesity 2021 Feb Gut Microbiome Profile after Pancreatectomy in Infants with Congenital Hyperinsulinism Vajravelu ME, Lee JJ, Mitteer L, Zemel BS, Bittinger K, De Leon DD Pancreas 2021 Jan 1 HIV Protease Inhibitor Ritonavir Impairs Endothelial Function Via Reduction in Adipose Mass and Endothelial Leptin Receptor-Dependent Increases in NADPH Oxidase 1 (Nox1), C-C Chemokine Receptor Type 5 (CCR5), and Inflammation Bruder-Nascimento T, Kress T, Kennard S, Belin de Chantemele, EJ. Journal of the American Heart Association 2020 Oct 6 Association between Prediabetes Diagnosis and Body Mass Index Trajectory of Overweight and Obese Adolescents Vajravelu ME, Lee JM, Shah R, Shults J, Amaral S, Kelly A Pediatric Diabetes 2020 Aug
Pharmacokinetic and Pharmacodynamic Profile of the Sodium-glucose Co-transporter-2 Inhibitor Empagliflozin in Young People With Type 2 Diabetes: A Randomized Trial Laffel LMB, Tamborlane WV, Yver A, Simons G, Wu J, Nock V, Hobson D, Hughan KS, Kaspers S, Marquard J Diabetic Medicine 2018 Apr 14
Impaired Lipolysis, Diminished Fat oxidation and Metabolic Inflexibility in Obese Girls with Polycystic Ovary Syndrome Kim JY, Tfayli H, Michaliszyn S, Arslanian S The Journal of Clinical Endocrinology & Metabolism 2018 Feb
Increased Lipolysis, Diminished Adipose Tissue Insulin Sensitivity and Impaired β-cell Function Relative to Adipose Tissue Insulin Sensitivity in Obese Youth with Impaired Glucose Tolerance (IGT) Kim JY, Nasr A, Tfayli H, Bacha F, Michaliszyn S, Arslanian S Diabetes 2017 Dec
Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate Hughan KS, Wendell SG, Delmastro-Greenwood M, Helbling N, Corey C, Bellavia L, Potti G, Grimes G, Goodpaster B, Kim-Shapiro DB, Shiva S, Freeman BA, Gladwin MT Hypertension 2017 Jul 24
Response to Letter “Pediatric Obesity – Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline.” Styne DM, Arslanian S, Connor EL, Farooqi IS, Murad H, Silverstein, JH, Yanovski JA The Journal of Clinical Endocrinology & Metabolism 2017 Jun 6
Pediatric Obesity – Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline Styne DM, Arslanian S, Connor EL, Farooqi IS, Murad H, Silverstein, JH, Yanovski JA The Journal of Clinical Endocrinology & Metabolism 2017 Jan 31
Adiponectin, Insulin Sensitivity, β-cell function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY TODAY Study Group: Arslanian S, El Ghormli L, Bacha F, Caprio S, Goland R, Haymond M, Levitsky L, Nadeau K, White N, Willi S Diabetes Care 2017 Jan
The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test Heralds Biomarkers of Type 2 Diabetes Risk in Obese Youth Kim JY, Michaliszyn SF, Nasr A, Lee SJ, Tfayli H, Hannon T, Hughan KS, Bacha F, Arslanian S Diabetes Care 2016 Aug
FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice Zhang T, Kim DH, Xiao X, Lee S, Gong Z, Muzumdar R, Calabuig-Navarro V, Yamauchi J, Harashima H, Wang R, Bottino R, Alvarez-Perez JC, Garcia-Ocaña A, Gittes G, Dong HH Endocrinology 2016 Mar
SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction Lai YC, Tabima DM, Dube JJ, Hughan KS, Vanderpool RR, Goncharov DA, St Croix CM, Garcia-Ocaña A, Goncharova EA, Tofovic SP, Mora AL, Gladwin MT Circulation 2016 Feb 23
Early Biomarkers of Subclinical Atherosclerosis in Obese Adolescent Girls with Polycystic Ovary Syndrome Hughan KS, Tfayli H, Warren-Ulanch JG, Barinas-Mitchell E, Arslanian S Journal of Pediatrics 2016 Jan
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