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Ewing sarcoma is the 2nd most common cancerous bone tumor that affects children, teens, and young adults. It's rare, with only about 250 cases each year in the U.S.
Most often, Ewing sarcoma starts in the bone or soft tissue. It can then spread to other organs, most commonly the lung.
Most Ewing sarcoma tumors occur in teens, but the disease can also happen at a younger age.
A chromosome rearrangement between chromosomes 11 and 22 causes most Ewing sarcoma cases, often involving the genes EWS and FLI1. This causes a fusion of genes referred to as a fusion transcript.
The fusion transcript changes gene expression and drives the cancer. Detecting this fusion transcript helps us diagnose Ewing sarcoma.
Though there's sometimes trauma or injury when diagnosed, it brings Ewing sarcoma to light rather than causes it.
While each child's symptoms may differ, the most common symptoms of Ewing sarcoma include:
The symptoms of Ewing sarcoma may mimic those of other health issues. Always consult your child's doctor for a diagnosis.
To diagnose your child, the doctor will take a complete health history and do a physical exam.
They'll also order tests and do other techniques, such as:
Ewing sarcoma can be tough to tell apart from other tumors like it. Doctors often have to exclude other common solid tumors and use genetic studies.
Your doctor will base your child's treatment on factors such as:
Treatment for Ewing sarcoma may include one or more of the following:
The prognosis for a child with Ewing sarcoma depends on:
As with any cancer, prognosis and long-term survival can vary greatly from child to child. Each child is unique.
We structure our treatment around your child's needs.
Prompt and aggressive care are vital for the best outlook. Follow-up care is also crucial.
Children who survive Ewing sarcoma can have late effects of radiation and chemo. The cancer can also recur.
Experts are always finding new and improved ways to treat Ewing sarcoma and to decrease side effects.
At UPMC Children's Hospital, our advanced training helps us give children and teens with Ewing sarcoma the best care.
Our combined team includes world-renowned experts in:
We also work with other experts, like those in pathology, nursing, physical and occupational therapy, and psychosocial services.
At UPMC Children's, we:
We're also a member of the Children's Oncology Group (COG) — the world's largest group devoted to childhood cancer research. This provides access to nearly 100 active clinical trials.
To learn more about treatment for Ewing sarcoma at UPMC Children's Hospital of Pittsburgh please call 724-386-6319.
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With MyCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Support the hospital by making a donation online, joining our Heroes in Healing monthly donor program, or visiting our site to learn about the other ways you can give back.