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Ranked #9 Nationally by U.S. News & World Report.
Recognized nationally and internationally, the Cardiovascular Research Laboratory at UPMC Children’s Hospital of Pittsburgh’s Rangos Research Center was designed to provide an environment in which researchers and clinicians could work side by side to study clinically relevant cardiovascular problems. The work here has gained worldwide respect and recognition in the field of congenital heart disease.
Congenital cardiovascular (CV) malformations represent one of the leading causes of morbidity and mortality in children and adults, however, it remains unclear how congenital CV malformations occur. Our research laboratories investigate the physiology and biomechanics of developing CV systems in chick and mouse embryos in order to better understand the structural and functional maturation of the normal heart and blood vessels and the causes for congenital heart disease.
Our laboratory has pioneered the integrated use of microinstruments to measure blood pressure, blood flow, and cardiac chamber dimensions in the 1 millimeter diameter embryonic heart. Because embryonic CV structural and functional maturation in chick and mouse embryos resembles human development, we can use these animal models to determine the relationship between biomechanical loading conditions and morphogenesis. For example, we have produced a model of hypoplastic left heart syndrome (HLHS) in the chick embryo by chronically reducing left ventricular filling via partial left-atrial ligation (LAL). We have also created experimental models of increased ventricular work via narrowing of the ventricular outflow tract (conotruncal banding - CTB) and by unilateral vitelline artery ligation (VAL).
In order to better understand the interactions between mother and fetus (in mammals) that may contribute to altered CV morphogenesis, we also investigate maternal and embryonic/fetal CV function in pregnant rodents using high resolution ultrasound as well as invasive techniques.
Our laboratory also serves as a core facility to determine CV structure and function in mature animals undergoing experimental protocols to evaluate novel therapies (cells, materials, devices, software) to treat congenital and acquired heart disease.
Researchers
Clinical Studies
Late Outcomes and Survival in Adults with Congenital Heart Disease Awaiting Cardiac Transplantation II
Comparison between Surgical vs. Balloon Angioplasty vs. Intravascular Stent Placement for Recurrent or Native Coarctation of the Aorta
Atrial Switch Database for Transposition of Great Arteries
Effect of Exercise on Serum Cardiac Biomarker Levels in Children and Adolescents
Mechanistic Clinical Trial of Beta-blocker Administration for Reactivating Cardiomyocyte Division in Tetralogy of Fallot
The Association of Kawasaki Disease and COVID-19 with Cardiac Complications: A Focused Sub-study of the International Kawasaki Disease Registry (IKDR)
Neurocognitive Function of Adolescents and Young Adults with Repaired Complex Congenital Heart Disease After Recent Cardiac Re-Interventions: A Pilot Study
Retrospective Review of PDA Closure with Medtronic MVP™ Micro Vascular Plug in Patients Weighing Less Than Two Kilograms
Advanced Cardiac Therapies Improving Outcomes Network (ACTION) to Improve the Health of Pediatric and Congenital Heart Disease Patients with Heart Failure
Clinical Trial Comparing Everolimus and Low-Dose Tacrolimus to Tacrolimus and Mycophenalate Mofetil at 6 Months Post Heart Transplant to Prevent Long-Term Complications after Pediatric Heart Transplantation
Prognosis of Pregnant Women with Congenital Heart Disease
ALK1 Signaling in Development of Superior Cavopulmonary Anastomosis-Associated Pulmonary Arteriovenous Malformations
Pulmonary Valve Perforation Study
Ductal Stenting vs. Surgical Shunt for Infants with Duct Dependent Pulmonary Blood Flow
Fetal Predictors of Pulmonary Valve Stenosis and Determining Post-Delivery Management
Pulmonary Vein Stenosis: Disease Mechanisms and Outcomes
Calcium Channel Blockers versus Beta Blockers in the Chronic Management of SVT in Pediatric Subjects without Pre-excitation Syndrome or Hemodynamically Significant Heart Disease
Transplant Epstein-Barr Virus (EBV) Disease – Pathogenesis and Immunotherapy
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
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