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Ranked #6 Nationally by U.S. News & World Report.
Named to US News & World Report list of top Pediatric Cardiology and Heart Surgery Programs.
The Heart Institute of UPMC Children’s Hospital of Pittsburgh is recognized nationally and internationally for its innovative clinical and laboratory research initiatives. Our researchers and clinicians work side-by-side to study clinically relevant cardiovascular problems in search of innovative solutions that will improve the lives of patients.
Congenital heart disease (CHD) is one of the Heart Institute’s primary areas of research focus. The most common of all birth defects, CHD affects 0.8% of newborns – nearly 40,000 babies born in the United States each year. As a result of improved diagnoses and advanced surgical techniques, there are now 2.4 million people living with CHD in the U.S., and our research programs seek to improve their lives.
Our research studies, many of which are sponsored by the National Institutes of Health and industry partners, are focused on delivering the best patient outcomes for our patients, families, and communities. Our most successful research initiatives begin with basic science discoveries in the laboratory. Then, in partnership with our clinical researchers, we bring our innovation to the bedside.
An example can be found in our investigations of congenital cardiovascular malformations. These represent one of the leading causes of morbidity and mortality in children and adults, yet it remains unclear how many congenital cardiovascular malformations occur. Our research laboratories investigate the physiology and biomechanics of developing cardiovascular systems in animal models and stem cells to better understand the structural and functional maturation of the normal heart and blood vessels and the causes of CHD. This knowledge is then further explored through our numerous clinical studies focused on CHD.
Through a unique collaboration, the Pediatric Institute for Heart Regeneration and Therapeutics, scientists and physicians from UPMC Children’s Hospital of Pittsburgh are pursuing groundbreaking investigations into how to make heart cells, called cardiomyocytes, replicate and proliferate to help the heart to heal itself in cases of heart failure or congenital defects.
Interactions between mother and fetus may also contribute to altered heart development. To better understand these interactions, we investigate maternal and embryonic/fetal cardiovascular function in animal models using high-resolution ultrasound and other advanced techniques.
In our research labs we also study cardiovascular structure and function in animal models as part of our evaluation of novel therapies using cells, advanced materials, medical devices, and software to help in the treatment of congenital and acquired heart disease.
Researchers
Clinical Studies
Late Outcomes and Survival in Adults with Congenital Heart Disease Awaiting Cardiac Transplantation II
Comparison between Surgical vs. Balloon Angioplasty vs. Intravascular Stent Placement for Recurrent or Native Coarctation of the Aorta
Atrial Switch Database for Transposition of Great Arteries
Effect of Exercise on Serum Cardiac Biomarker Levels in Children and Adolescents
Mechanistic Clinical Trial of Beta-blocker Administration for Reactivating Cardiomyocyte Division in Tetralogy of Fallot
The Association of Kawasaki Disease and COVID-19 with Cardiac Complications: A Focused Sub-study of the International Kawasaki Disease Registry (IKDR)
Neurocognitive Function of Adolescents and Young Adults with Repaired Complex Congenital Heart Disease After Recent Cardiac Re-Interventions: A Pilot Study
Retrospective Review of PDA Closure with Medtronic MVP™ Micro Vascular Plug in Patients Weighing Less Than Two Kilograms
Advanced Cardiac Therapies Improving Outcomes Network (ACTION) to Improve the Health of Pediatric and Congenital Heart Disease Patients with Heart Failure
Clinical Trial Comparing Everolimus and Low-Dose Tacrolimus to Tacrolimus and Mycophenalate Mofetil at 6 Months Post Heart Transplant to Prevent Long-Term Complications after Pediatric Heart Transplantation
Prognosis of Pregnant Women with Congenital Heart Disease
ALK1 Signaling in Development of Superior Cavopulmonary Anastomosis-Associated Pulmonary Arteriovenous Malformations
Pulmonary Valve Perforation Study
Ductal Stenting vs. Surgical Shunt for Infants with Duct Dependent Pulmonary Blood Flow
Fetal Predictors of Pulmonary Valve Stenosis and Determining Post-Delivery Management
Pulmonary Vein Stenosis: Disease Mechanisms and Outcomes
Calcium Channel Blockers versus Beta Blockers in the Chronic Management of SVT in Pediatric Subjects without Pre-excitation Syndrome or Hemodynamically Significant Heart Disease
Transplant Epstein-Barr Virus (EBV) Disease – Pathogenesis and Immunotherapy
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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