Pulmonary Medicine Research

Illness from lung infections is the leading reason children visit doctors in the United States each year. And worldwide, lung infections are the number-one cause of death among children. Recognizing that the susceptibility to respiratory infections is an interplay between microbe and host, researchers at UPMC Children’s Hospital of Pittsburgh are leading the charge against respiratory illness on multiple fronts: from asthma, pneumonia, bronchitis, cystic fibrosis and tuberculosis to sleep disorders and exotic conditions such as pulmonary lymphangiectasia and plastic bronchitis.

Children’s unique Laboratory of Lung Immunology and Host Defense is investigating the immune response to various lung pathogens. By understanding immune responses that confer protection against infection with damaging the lung, these immune responses can be exploited for novel vaccine approaches or immune-based therapies to prevent or treat lung infections. The lab is internationally known in the area of lung inflammation and Pneumocystis research and is well funded by the National Institutes of Health. It is also a recipient of one of three Specialized Centers of Clinically Oriented Research grants in the area of Host Factors in Chronic Lung Disease.

Investigating the causes and treatment of cystic fibrosis, Children’s Cystic Fibrosis Center is one of the largest of its kind in the country. There, researchers examine lung infection down to the cellular and molecular level to gain a better understanding of how the lungs protect themselves, and then to use this knowledge to develop innovative therapies.

Research into the genetic and environmental causes of asthma and its treatment is a core focus of the Pediatric Asthma Center.

Children’s has one of the nation’s largest bronchoscopy services, which offers technologically advanced pulmonary function testing. Studies to assess upper airway function and the regulatory mechanisms of breathing can be performed on young children and even tiny infants. Today, our understanding of lung infections and diseases is undergoing a revolution, while Children’s well-respected pulmonology and allergy/immunology research teams has emerged as a pioneer in this research. 


Clinical Studies

Asthma & Epigenetic Variation in Puerto Rican Children: The EVA-PR Study

Epigenetic Variation and Childhood Asthma in Puerto Ricans (EVA-PR)

Read more

Asthma & the Impact of Stress on Treatment Response: The STAR Study

Stress and Treatment Response in Puerto Rican Children with Asthma (STAR)

Read more

Asthma Attacks & Vitamin D Deficiency – Phase II

Vitamin D to Prevent Severe Asthma Exacerbations (Vit-D-Kids Asthma)

Read more

Asthma, Epigenetic Variation & Exposure to Violence in Puerto Rican Children

Exposure to Violence, Epigenetic Variation, and Childhood Asthma in Puerto Ricans

Read more

Asthma Treatment with Steroids: The SIENA Study – Phase III

Steroids in Eosinophil-Negative Asthma (SIENA)

Read more

Biomarkers of Lung Disease

Biomarkers of Lung Disease in Bronchoalveolar Lavage Fluid

Read more

Cough Study for Males with Neuromuscular Disease – Pilot

Cough Peak Flow And Airway Clearance in Pediatric Patients with Neuromuscular Disease

Read more

Cystic Fibrosis CFTR Therapy Outcomes Analysis: The CHEC-SC Cohort Study

Characterizing CFTR Modulated Changes in Sweat Chloride and their Association with Clinical Outcomes

Read more

Cystic Fibrosis MRSA Lung-Infection Treatment with AeroVanc – Phase III

Study of AeroVanc for the Treatment of Persistent Methicillin-Resistant Staphylococcus aureus Lung Infection in Cystic Fibrosis Patients

Read more

Cystic Fibrosis Patient Registry

Participation in the Cystic Fibrosis Patient Registry

Read more

Cystic Fibrosis Therapy Using Saline Hypertonic: The SHIP-CT Study – Phase II/III

Saline Hypertonic in Preschoolers With Cystic Fibrosis and Lung Structure as Measured by Computed Tomography

Read more

Cystic Fibrosis Treatment with LAU-7b: The APPLAUD Study – Phase II

Study of the Efficacy and Safety of LAU-7b in the Treatment of Cystic Fibrosis in Adults

Read more

Cystic Fibrosis Treatment with Lenabasum – Phase II

Trial to Evaluate Efficacy and Safety of Lenabasum in Cystic Fibrosis

Read more

Severe Asthma Investigation

Severe Asthma Research Program: Inflammation, Myofibroblasts and Loss of Elastic Recoil in Severe Asthma

Read more