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Illness from lung infections is the leading reason children visit doctors in the United States each year. And worldwide, lung infections are the number-one cause of death among children. Recognizing that the susceptibility to respiratory infections is an interplay between microbe and host, researchers at UPMC Children’s Hospital of Pittsburgh are leading the charge against respiratory illness on multiple fronts: from asthma, pneumonia, bronchitis, cystic fibrosis and tuberculosis to sleep disorders and exotic conditions such as pulmonary lymphangiectasia and plastic bronchitis.
Children’s unique Laboratory of Lung Immunology and Host Defense is investigating the immune response to various lung pathogens. By understanding immune responses that confer protection against infection with damaging the lung, these immune responses can be exploited for novel vaccine approaches or immune-based therapies to prevent or treat lung infections. The lab is internationally known in the area of lung inflammation and Pneumocystis research and is well funded by the National Institutes of Health. It is also a recipient of one of three Specialized Centers of Clinically Oriented Research grants in the area of Host Factors in Chronic Lung Disease.
Investigating the causes and treatment of cystic fibrosis, Children’s Cystic Fibrosis Center is one of the largest of its kind in the country. There, researchers examine lung infection down to the cellular and molecular level to gain a better understanding of how the lungs protect themselves, and then to use this knowledge to develop innovative therapies.
Research into the genetic and environmental causes of asthma and its treatment is a core focus of the Pediatric Asthma Center.
Children’s has one of the nation’s largest bronchoscopy services, which offers technologically advanced pulmonary function testing. Studies to assess upper airway function and the regulatory mechanisms of breathing can be performed on young children and even tiny infants. Today, our understanding of lung infections and diseases is undergoing a revolution, while Children’s well-respected pulmonology and allergy/immunology research teams has emerged as a pioneer in this research.
Epigenetic Variation and Childhood Asthma in Puerto Ricans (EVA-PR)
Stress and Treatment Response in Puerto Rican Children with Asthma (STAR)
Vitamin D to Prevent Severe Asthma Exacerbations (Vit-D-Kids Asthma)
Exposure to Violence, Epigenetic Variation, and Childhood Asthma in Puerto Ricans
Steroids in Eosinophil-Negative Asthma (SIENA)
Biomarkers of Lung Disease in Bronchoalveolar Lavage Fluid
Cough Peak Flow And Airway Clearance in Pediatric Patients with Neuromuscular Disease
Characterizing CFTR Modulated Changes in Sweat Chloride and their Association with Clinical Outcomes
Standardized Treatment of Pulmonary Exacerbations II
Study of AeroVanc for the Treatment of Persistent Methicillin-Resistant Staphylococcus aureus Lung Infection in Cystic Fibrosis Patients
Participation in the Cystic Fibrosis Patient Registry
Saline Hypertonic in Preschoolers With Cystic Fibrosis and Lung Structure as Measured by Computed Tomography
Study of the Efficacy and Safety of LAU-7b in the Treatment of Cystic Fibrosis in Adults
Trial to Evaluate Efficacy and Safety of Lenabasum in Cystic Fibrosis
Severe Asthma Research Program: Inflammation, Myofibroblasts and Loss of Elastic Recoil in Severe Asthma
John Alcorn, PhD
Nadia Boutaoui, PhD
Wei Chen, PhD
Yueh-Ying Han, PhD, MS
Jieru Wang, PhD, MS
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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