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Ranked #6 Nationally by U.S. News & World Report.
The Division of Pediatric Endocrinology, Diabetes and Metabolism at UPMC Children’s Hospital of Pittsburgh is world renowned for its 4 decades of Pediatric Endocrine research, particularly in the area of diabetes and carbohydrate-related metabolic disorders.
Research into the etiology and epidemiology of type 1 diabetes evaluates the immunologic, genetic and environmental determinants in a search for triggers that precipitate clinical diabetes. Prevention of clinical diabetes as well as the physical and psychosocial complications of diabetes and preservation of insulin secretory capacity are the ultimate goals of the research of both local populations and national and international collaborations. Our researchers were amongst the first to recognize the coexistence of features of type 1 and type 2 diabetes and coined the term “double diabetes” Both epidemiologic and intervention strategies are ongoing. In one of the major international intervention study, Children’s serves as the coordinating center for the United States. In that study, researchers are comparing use of hydrolyzed formulas in genetically susceptible infants. If the intervention is effective in delaying autoimmunity or its progression to diabetes, this first-ever primary prevention study of type 1 diabetes will have a far-reaching impact for individuals and the global society.
Type 2 diabetes, a disease once considered almost exclusive to adults, is increasing at an alarming rate among children. Research into the areas of hormones related to childhood obesity, insulin sensitivity/resistance, prediabetes and cardiovascular disease in youth has led to an increased awareness of this epidemic and racial differences in its pathogenesis. This resulted in validated patient care approaches leading to new trials aimed at type 2 diabetes intervention by our nationally recognized faculty.
Beyond the scope of clinical diabetes, research is progressing in the study of growth hormone and its receptors in rodent models using a conditional knockout genetic approach. A number of clinical growth hormone studies supported by pharmaceutical research, include the GeNeSIS study with a primary goal of evaluating the long-term safety and efficacy of growth hormone use for children with endocrine or growth disorders with 5 substudies: DNA Analysis, Growth Prediction, SHOX Deficiency, Neoplasia and Idiopathic Short Stature. The idiopathic short stature study assesses the effect of different growth hormone doses in short children without growth hormone deficiency. The need to identify and characterize the clinical, endocrine and other features within this area take into consideration not only the physical patient care, but the psychosocial factors, stressing the important of this research, as endocrine disorders affect quality of life throughout the transition from childhood into adolescence.
Study to Evaluate the Safety and Efficacy of Crinecerfont (NBI-74788) in Adult Subjects with Classic Congenital Adrenal Hyperplasia, Followed by Open-Label Treatment
Autologous Dendritic Cell Therapy for Type 1 Diabetes Suppression: A Safety Study
The Genetics and NeuroEndocrinology of Short Stature International Study (GeNeSIS) Consent For Data Collection: Core Program
Genentech National Cooperative Growth Study Surveillance Program for Nutropin, Nutropin AQ and Protropin
KIGS: Pfizer International Growth Study for Genotropin®
Etiology and Epidemiology of Type 1 Diabetes
TEDDY Study - The Environmental Determinants of Diabetes in the Young
Effects of CTLA-4 Ig on The Progression of Type 1 Diabetes in New Onset Subjects
Screening and the Natural History Study of the Development of Type 1 Diabetes
Effects of GAD-Alum on the Progression of Type 1 Diabetes in New Onset Subjects
Oral Insulin for Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes Mellitus
The Effect of Rituximab on the Progression of Type 1 Diabetes
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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