Newborn Medicine Research

The Division of Newborn Medicine maintains several active research programs.The Division of Newborn Medicine maintains several active research programs, from National Institutes of Health-funded basic research to collaborative, multi-center clinical trials. Current areas of investigation include respiratory muscle function and fatigue, brain blood flow and its relation to brain injury in premature infants, chronic lung disease, and gastro-esophageal reflux disease.

Using a genome-based approach, the lab has pioneered studies of a family of proteins called serpins, which protect cells from injury. An investigation is underway to examine how serpins work in normal development as well as the role they play in certain cancers and infections.

Other areas of interest include:


Clinical Studies

Cool Cap Long-term Follow-up Study

Neurodevelopmental Outcome at Age 7 After Selective Head Cooling with Mild Systemic Hypothermia After Neonatal Encephalopathy

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Genome Sequencing of Infants in the ICU: The PISCES Study

Whole Genome Sequencing in the Intensive Care Unit Population

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Infection Treatment with Ceftobiprole – Phase I

Evaluation of the Single Dose Pharmacokinetics and Safety of Ceftobiprole in Neonate and Infant Subjects Aged up to 3 Months Undergoing Treatment With Systemic Antibiotics

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Preterm Infant Feeding Study

Feeding During Ibuprofen or Indomethacin Treatment of Preterm Infants for a patent ductus arteriosus (PDA)

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Staph Antibody Study

Trial to Evaluate Pagibaximab in Very Low Birth Weight Neonates for the Prevention of Staphylococcal Sepsis

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Venous Thromboembolism Treatment with Apixaban – Phase IV

Study of Pediatric Subjects Requiring Anticoagulation for the Treatment of a Venous Thromboembolic Event

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Additional Researchers

Thomas Hooven, MD