General Academic Pediatrics Research

With an international reputation for research focused on ear infections, the Division of General Academic Pediatrics of UPMC Children’s Hospital of Pittsburgh continues to explore treatment strategies for acute otitis media (AOM). These efforts are well funded and include support from the National Institutes of Health. Additionally, the division has taken on a leadership role as a Clinical Treatment Center for a nationwide study to evaluate the effectiveness of certain antimicrobials in preventing recurrences of urinary tract infections in infants with vesicoureteral reflux.

Among the division’s far-reaching areas of study are exploration of the relationship between maternal mental health and child outcomes; and vitamin D insufficiency and calcium nutrition among preadolescent African-American children.

Researchers

Clinical Studies

Acute Sinusitis & Antibiotics

Efficacy of Antibiotics in Children with Acute Sinusitis: Which Subgroups Benefit?

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COVID-19 Adult Booster Vaccine Study – Phase II/III

Delayed Heterologous SARS-CoV-2 Vaccine Dosing (Boost) After Receipt of EUA Vaccines

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COVID-19 Vaccine for Children: The KidCOVE Study – Phase II/III

A Study to Evaluate Safety and Effectiveness of mRNA-1273 COVID-19 Vaccine in Healthy Children Between 6 Months of Age and Less Than 12 Years of Age

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D3VH Study – Vitamin D and Vascular Health

Vitamin D3 and Vascular Health in Obese Children

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Defining Vitamin D Insufficiency

Defining Vitamin D Insufficiency in School-Age Children: A Randomized Placebo-Controlled Trial of Vitamin D3

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Flu Study

Option B Children & Adolescent RCT: Immunologic Response to Influenza Vaccination in Children and Adolescents

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Meningitis Combination Vaccine

Combined Meningococcal Groups A, B, C, W, and Y vaccine (GSK3536819A) Phase IIIB Clinical Trial

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Meningococcal Study

Safety and immunogenicity of Men B when administered concomitantly with Men ACWY vaccine to healthy subject 16-18 years of age

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New Vaccine Surveillance Network (NVSN) - Healthy Controls

Enhanced active surveillance of pediatric infectious diseases and vaccines and Enhanced Active Surveillance of Pediatric Respiratory Infections and Vaccine Preventable Diseases

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OP0201 as an Adjunct Treatment for Acute Otitis Media

Assess the Safety, Tolerability, and Efficacy of OP0201 as an Adjunct Treatment for Acute Otitis Media in Infants and Children Aged 6 to 24 Months

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Pneumonia – Short Course Therapy

Short Course vs. Standard Course Outpatient Therapy for Community Acquired Pneumonia in Children

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Recurrent Acute Otitis Media

Efficacy of Tympanostomy Tubes for Children with Recurrent Acute Otitis Media

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RSV Prevention Research Study

A phase 2b/3 Double-Blind, Randomized, Placebo-controlled Study to evaluate the efficacy of MK-1654 in Healthy Pre-term and Full-term infants

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Safety and Efficacy of MEDI8897 Against RSV

Safety and Efficacy of MEDI8897 Against RSV

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Safety and Efficacy of MEDI8897 against RSV (MELODY Study)

A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of MEDI8897, a Monoclonal Antibody With an Extended Half-life Against Respiratory Syncytial Virus, in Healthy Late Preterm and Term Infants (MELODY)

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TAP Study

Tympanocentesis to Assess Pathogens Study  

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Treatment of Acute Otitis Media (AOM), 10 versus 5 Days of Antibiotics

Efficacy of Short-Course Antimicrobial Treatment for Young Children With Acute Otitis Media and Impact on Antimicrobial Resistance

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Urinary Tract Infection NIH Observational Study (CUTIE)

Careful Urinary Tract Infection Evaluation (CUTIE) Study of Risk Factors for Renal Scarring in Children after Urinary Tract Infection

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Urinary Tract Infection - Short Course Therapy (SCOUT Study)

Short COurse Therapy for Urinary Tract Infections in Children (SCOUT)

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Urinary Tract Infection Treatment with Corticosteroids (STARRS Study)

STeroids to Actively Reduce Renal Scarring (STARRS): Corticosteroids for Children with Febrile Urinary Tract Infections

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