Emergency Medicine Research

Research in the Division of Pediatric Emergency Medicine at UPMC Children’s Hospital of Pittsburgh is helping set new standards of care, both for first responders who transport infants and children in life-threatening situations and for the emergency department medical teams that treat them.

The division has a robust clinical research infrastructure including a dedicated research office adjacent to the Emergency Department. Our clinical researchers are led by Robert W. Hickey, MD, and supported by four registered nurses and four research assistants. In recent years, the division’s clinical research team has annually enrolled, on average, about 1,200 children in various studies.

Our key studies are funded by the National Institutes of Health (NIH) and the Centers for Disease Control and Prevention, and the division is a member of the prestigious Pediatric Emergency Care Applied Research Network, a consortium of 18 children’s hospitals performing large-scale pediatric emergency medicine research studies funded by the federal government.

Recent clinical research programs by the division have examined treatment of urinary tract infections, treatment of concussion, management of young febrile infants, diagnosis of pneumonia, identification of cervical spine injuries, non-invasive diagnosis of strep throat, and prevalence of influenza, to name a few.

With NIH support, basic and translational research by the Division of Pediatric Emergency Medicine is led by Mioara Manole, MD, FAAP, and includes investigations into pediatric asphyxial cardiac arrest, adult cardiac arrest, and pediatric and adult traumatic brain injury. Our state-of-the-art translational laboratory is also part of the internationally recognized Safar Center for Resuscitation Research.


  • Robert Hickey, MD
  • Maren Lunoe, MD
  • Mioara Manole, MD, FAAP
  • Jennifer Marin, MD, MSc
  • Desiree Noel Wagner Neville, MD
  • Kathleen Noorbakhsh, MD
  • Sylvia Owusu Ansah, MD
  • Richard Saladino, MD
  • Srinivasan Suresh, MD, MBA, FAAP
  • Melissa Tavarez, MD
  • Noel Zuckerbraun, MD, MPH

Clinical Studies

Acute Gastroenteritis (AGE) and Acute Respiratory Illness (ARI) in Children

Enhanced Active Surveillance of Pediatric Infectious Disease and Vaccine by the New Vaccine Surveillance Network

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COVID-19 Testing in Children via Saliva Samples: The SPITS MISC Study

Severity Predictors Integrating Salivary Transcriptomics and Proteomics with Multi-neural Network Intelligence in SARS-CoV2 Infection in Children

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Influenza Vaccine Effectiveness: The Flu VE Study

U.S. Flu Vaccine Effectiveness Network: Pittsburgh

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Lyme Disease Diagnosis Study

Novel Diagnostics for Lyme Disease

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Pediatric Concussion Treatment via Active Injury Management

Active Injury Management (AIM) after Pediatric Concussion

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Pulmonary Embolism Diagnosis in Emergency Setting: The BEEPER Study

Bedside Exclusion of Pulmonary Embolism in Children without Radiation

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Seizure Medication Dosing Protocol: The PediDOSE Study – Phase III

Pediatric Dose Optimization for Seizures in EMS (PediDOSE)

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Sepsis Treatment Comparing Intravenous Solutions: The PRoMPT BOLUS Study – Phase III

Balanced Fluid Resuscitation to Decrease Kidney Injury in Children with Septic Shock

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Wheezing Treatment with Azithromycin Therapy: The AZ-SWED Study – Phase III

Azithromycin Therapy in Preschoolers with a Severe Wheezing Episode Diagnosed at the Emergency Department

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