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As many as six naturally occurring missense mutations have been introduced into recombinant isovaleryl Coenzyme A dehydrogenase (IVD) cloned in a prokaryotic expression vector. Four were stable enough to produce, and two failed to produce protein in the cell free extract. Three of the four had activity. Our lab is characterizing these mutants and their thermal stability, as they will be potential targets for therapy.
Al-Walid A. Mohsen, PhD
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Support the hospital by making a donation online, joining our Heroes in Healing monthly donor program, or visiting our site to learn about the other ways you can give back.