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This Phase III study explores methods to reduce the risk of infections and sepsis in children undergoing treatment in pediatric intensive care units (PICUs). Researchers believe it is possible that daily doses of the drug metoclopramide as well as nutritional supplements zinc, selenium and glutamine will reduce the likelihood of new infections and sepsis from occurring in critically ill children. Children’s Hospital of Pittsburgh of UPMC is leading this study involving 7 U.S. hospitals and 600 participants.
Critically ill boys and girls from ages 1 to 17 may take part in this research study if they meet eligibility requirements. Among those requirements, participants must have as a potential source of infection, at least one of the following: a potential source of infection involving either a mechanical ventilation tube for breathing, a urinary catheter, or a central venous catheter.
Boys: 1 to 17 years
Girls: 1 to 17 years
While in the PICU, children will be given the nutritional supplements through a feeding tube, and the drug metoclopramide through an intravenous line.
Visits: Occurs during hospitalization
Duration: Up to 28 days, depending on the severity of the participant’s illness
National Institute of Child Health and Human Development
Study Description at National Institutes of Health
Joseph A. Carcillo, MD
To get started, please contact:
Joseph A. Carcillo, MD
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