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This trial by the Pediatric Brain Tumor Research Consortium studies the side effects and best dose of CDK 4-6 Inhibitor PD-0332991, also known as palbociclib isethionate, in treating younger patients with central nervous system tumors that have grown, come back, or not responded to treatment. Palbociclib isethionate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Subject to certain exclusion criteria, this study is open to males and females, ages 4 to 21 years, who have histologically confirmed Rb1 positive primary recurrent, progressive, or refractory central nervous system tumors.
Males and Females: Ages 4 to 21 years
Following an initial screening exam, study participants will receive palbociclib isethionate orally once daily for 21 days followed by a 7-day break. This 4-week course will extend to 26 courses in the absence of disease progression or unacceptable toxicity. Blood draws, EKGs and brain scans will be conducted, among other tests, at periodic intervals.
Visits: Weekly during first month of therapy, followed by monthly visits and periodic lab testing in subsequent months
Duration: Approximately 2 years
Pediatric Brain Tumor Consortium (Study PBTC-042)
Study Description at National Institutes of Health
Cancer and Blood Disorder Research
A. Kim Ritchey, MD
For more information about the study or enrollment, please contact:
Research Coordinator Angela Connelly, RN, BSN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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