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This Pediatric Brain Tumor Research Consortium trial is studying selumetinib, also known as AZD6244, in treating young patients with brain tumors. Researchers are studying the effects of varying dosage levels for patients ages 12 and up, and for patients under the age of 12. AZD6244 has been studied in adults, however it has not been previously studied in pediatric patients.
Study Level: Phase II
Subject to certain exclusion criteria, this study is open to males and females, ages 3 to 21 years old, who have a brain tumor that is growing or has come back.
Males and Females: Ages 3 to 21 years
Following an initial physical exam, participants will take a selumetinib capsule twice a day over a course of 28 days, for up to 26 courses. At specific intervals, researchers will require other tests, including bloodwork to measure how the study drug is being absorbed into the blood. MRI scans of the brain tumor will also be done after specific intervals.
Duration: Approximately 2 years
Pediatric Brain Tumor Consortium (Study PBTC-029B)
National Cancer Institute
Study Description at National Institutes of Health
Cancer and Blood Disorder Research
Alberto Broniscer, MD
For more information about the study or enrollment, please contact:
Research Coordinator Sharon Dibridge
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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