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The goal of this multi-center Children’s Oncology Group study is to study the effects of the combination of blinatumomab and nivolumab on people who have experienced their first relapse of B-cell acute lymphoblastic leukemia (B-ALL) following prior treatment, as compared to treatment using blinatumomab without nivolumab.
Subject to certain exclusion criteria, this study is enrolling patients ages 1 through 30 years, who have been diagnosed with first bone marrow relapse of B-ALL. For participants under age 18, relapse must have occurred less than 24 months after initial diagnosis. Males and Females: Ages 1 through 30 years
Participants will be randomly selected to receive, via intravenous infusion, either the medicine blinatumomab alone or with nivolumab as part of a 5-week immunotherapy cycle. Participants may receive up to 2 cycles of immunotherapy. Initial days of each cycle require hospitalization for observation and testing, and return visits are required throughout the cycle period. It is recommended that participants proceed to hematopoietic stem cell transplant upon completion of immunotherapy. Visits: The number of visits varies based on participant response to therapy. Duration: About 2-1/2 months for treatment in most cases, and 5 years for long term follow-up.
Children’s Oncology Group (AALL1821) National Cancer Institute
Study Description at the National Institutes of Health Cancer and Blood Disorder Research Leukemia Overview and Causes
A. Kim Ritchey, MD
For more information about the study or enrollment, please contact the UPMC Children’s Hospital of Pittsburgh Hematology-Oncology research team, at: HOCHPPhaseI-II@upmc.edu.
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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