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Through this multi-center investigation by the Children’s Oncology Group, researchers will study how well bosutinib, when given at the most favorable dose, works in children with chronic myeloid leukemia (CML). Bosutinib is a tyrosine kinase inhibitor (TKI) that has a different side-effect profile than TKIs typically used in treatment of CML. TKIs help block the action of a type of protein kinase or enzyme called tyrosine kinase, which can help prevent the cancer cells from growing.
Subject to certain exclusion criteria, this study is enrolling patients ages 1 through 17, who have been diagnosed with CML.
Boys and Girls: Ages 1 through 17 years
The first part of the study is focused on determining the most favorable dose that can be given safely, and the second part monitors effects over a longer term. The drug will be taken orally over the course of multiple 28-day cycles with visits for examinations and tests during each of the first 7 cycles, then every third cycle thereafter.
Visits: Number varies based on participant response to therapy.
Duration: Depends on participant response to drug and may last up to 2 years after the last participant joins the first part of the study, with long-term follow-up for 10 years.
Children’s Oncology Group (AAML1921)
National Cancer Institute
Study Description at the National Institutes of Health
Cancer and Blood Disorder Research
Leukemia Overview and Causes
Andrew Bukowinski, MD
For more information about the study or enrollment, please contact the UPMC Children’s Hospital of Pittsburgh Hematology-Oncology research team, at:
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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