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This multicenter trial by the Children’s Oncology Group studies brentuximab vedotin and combination chemotherapy to see how well they work compared to combination chemotherapy alone in treating younger patients with newly diagnosed Hodgkin lymphoma. Researchers believe that brentuximab vedotin may be able to carry cancer-killing substances directly to Hodgkin lymphoma cells.
Subject to certain exclusion criteria, this study is open to patients of both genders, ages 2 to 18 years, newly diagnosed with classical Hodgkin lymphoma.
Males and Females: Ages 2 to 18 years
Patients enrolled in the study will be randomly placed in one of two treatment plans. One will receive standard chemotherapy and the other will receive chemotherapy similar to standard treatment, but with the addition of brentuximab vedotin and the omission of bleomycin. After the 2 initial 21-day cycles, an evaluation will be done with imaging scans to see how the disease is responding. For patients whose condition has not gotten worse, 3 more cycles of chemotherapy will be done, followed by radiation therapy, if needed.
Visits: Same number as required for standard chemotherapy
Duration: 3 to 4 months
Children’s Oncology Group (AHOD1331)
National Cancer Institute
Study Description at National Institutes of Health
Cancer and Blood Disorder Research
Peter Shaw, MD
For more information about the study or enrollment, please contact:
Peter Shaw, MD
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UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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