Neuroblastomas Clinical Studies

Some of the many Cancer and Blood Disorders research opportunities available related to neuroblastomas are listed below. Select a study to review a brief description and requirements. Parents or guardians of children who might be eligible are encouraged to inquire about enrollment. Contact information is provided at the end of each study.

Please note that Pilot and Phase I studies are the most experimental and should be considered only after other treatments or trials have been attempted without success.

Thank you for exploring these opportunities and helping us to find cures and prevent childhood disease.

Clinical Studies

Researchers

Children’s Oncology Group Long-Term Follow-up of Study Participants

ALTE05N1: Umbrella Long-Term Follow-Up Protocol for Participants with and without a History of Cancer

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Children’s Oncology Group’s Project: EveryChild

APEC14B1: Project:Every Child, A Registry, Eligibility Screening, Biology and Outcome Study

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Fitness Program for Adolescent and Young Adult Childhood Cancer Survivors: The StepByStep Study – Phase III

ALTE2031: StepByStep: A Trial of a Mobile Health and Social Media Physical Activity Intervention Among Adolescent and Young Adult Childhood Cancer Survivors

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Fitness Program for Children and Adolescents Following Cancer Therapy – Phase III

ALTE1631: A Web-based Physical Activity Intervention among Children and Adolescents

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Neuroblastoma Biology Studies

ANBL00B1: Neuroblastoma Biology Studies

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Neuroblastoma Treatment Guided by Biology-Based Risk Factors – Phase III

ANBL1232: Utilizing Response- and Biology-based Risk Factors to Guide Therapy in Patients with Non-High-Risk Neuroblastoma

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Neuroblastoma Treatment Using 131I-MIBG or Lorlatinib – Phase III

ANBL1531: Study of 131I-Metaiodobenzylguanidine or ALK Inhibitor Therapy Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma

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Neuroblastoma Treatment Using Eflornithine in Chemotherapy – Phase II

ANBL1821: Study of Irinotecan/ Temozolomide/ Dinutuximab with or without Eflornithine in Children with Relapsed, Refractory, or Progressive Neuroblastoma

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Pediatric Tumors and Specimen Study

ACNS02B3: A Children’s Oncology Group Protocol for Collecting and Banking Pediatric Specimens Including Rare Pediatric Tumors

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Solid Tumor Treatment with MLN4924, Temozolomide & Irinotecan

ADVL1615: Study of Pevonedistat (MLN4924), a NEDD8-Activating Enzyme Inhibitor, in Combination with Temozolomide and Irinotecan in Pediatric Patients with Recurrent or Refractory Solid Tumors

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Solid Tumor Treatment with Palbociclib – Phase I

ADVL1921: Study to Evaluate the Safety and Pharmacokinetics of Palbociclib (IBRANCE®) in Combination with Irinotecan and Temozolomide in Pediatric Patients with Recurrent or Refractory Solid Tumors

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