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The goal of this Children's Oncology Group study is to determine the effects and tolerability of adding the drug eflornithine to chemotherapy using irinotecan, temozolomide, and dinutuximab for people with neuroblastoma that has come back after treatment (relapsed) or has not responded to treatment (refractory).
Subject to certain exclusion criteria, this study is enrolling patients ages 1 year and older who have been diagnosed with relapsed or refractory neuroblastoma. Males and Females: Ages 1 year and older
Participants will be randomly assigned to receive either a standard COG-recommended chemotherapy regimen or the standard regimen with eflornithine added to each cycle of therapy. Participants will receive up to 6 cycles of therapy, each lasting 28 days, with evaluations to test tumor response conducted after every 2 cycles. Patients may receive 11 additional cycles for a total of 17 cycles if they do not achieve complete response, partial response or had only minor response to the initial therapy. Visits: Number of visits can vary by individual. Duration: About 5-1/2 months of therapy for most participants.
Children’s Oncology Group (ANBL1821) National Cancer Institute
Study Description at the National Institutes of Health Cancer and Blood Disorder Research
Jean M. Tersak, MD
For more information about the study or enrollment, please contact the UPMC Children’s Hospital of Pittsburgh Hematology-Oncology research team, at: HOCHPPhaseI-II@upmc.edu
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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