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Through this Children’s Oncology Group (COG) study, researchers are evaluating the effectiveness of the drug MK-1775 (AZD1775) given in combination with irinotecan against recurrent tumors and tumors that will not respond to standard therapy. MK-1775 has shown potential in laboratory tests. This program evaluates the effects of the drug on tumors, as well as its side effects and how the body processes it. This study is an initiative of COG’s Pediatric Early Phase Clinical Trial Network of which UPMC Children’s Hospital of Pittsburgh is a part.
Participants will take MK-1775 and irinotecan orally once a day for the first 5 days of a 21-day cycle. During the study, participants will have tests and procedures such as imaging and blood draws, as well as physical examinations at specific intervals. Participants may remain in the study for up to 18 cycles, unless they develop serious side effects or their tumors worsen.
Visits: The same number as with standard care for these conditions.
Duration: Up to 18 cycles of therapy (about a year)
Children’s Oncology Group (ADVL1312)
National Cancer Institute
Study Description at National Institutes of Health
Cancer and Blood Disorder Research
Jean Tersak, MD
For more information about the study or enrollment, please contact:
Andrew Bukowinski MD, MS
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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