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Through this multi-center Children’s Oncology Group study, researchers are evaluating the effects of the drug lenvatinib administered in combination with everolimus once daily to participants with recurrent/refractory solid tumors, as classified: Ewing sarcoma, peripheral primitive neuroectodermal tumor, rhabdomyosarcoma, or high-grade glioma. Researchers will be assessing the activity of the drugs in combination, their effects on tumors and how the body processes them.
Subject to certain exclusion criteria, this study is enrolling participants, ages 2 to 21 years, who have one of the cancers mentioned above.
Males and Females: Ages 2 to 21 years
In 4-week cycles, participants will take the study drugs orally, once a day. While taking the study drug, participants will need to visit the clinic for blood draws and examinations. Participants may remain in the study while it is active, unless serious side effects occur or the participant’s tumor worsens.
Visits: 5 in the first cycle, 4 in the second cycle and 3 in each subsequent cycle
Duration: Open ended
Children’s Oncology Group (ADVL1711)
Study Description at National Institutes of Health
Cancer and Blood Disorder Research
Jean Tersak, MD
For more information about the study or enrollment, please contact:
Andrew Bukowinski, MD, MS
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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