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The purpose of this multi-center international study is to determine the safety profile and effects of voriconazole to treat different kinds of serious fungal infections in children. Researchers are investigating voriconazole as primary therapy for treatment of invasive aspergillosis and molds such as scedosporium or fusarium species in pediatric patients.
Subject to certain exclusion criteria, this study is open to patients of both genders, ages 2 through 17, who have been diagnosed with proven, probable or possible invasive aspergillosis or a rare mold infection.
Boys: Ages 2 through 17
Girls: Ages 2 through 17
Participants will be enrolled in the study for 6 to 12 weeks. For at least the first 7 days of the study, participants will receive intravenous (IV) does of voriconazole every 12 hours in the hospital. With significant clinical improvement, participants will be switched to an oral regimen that may be able to be taken at home.
Visits: Requires hospitalization for initial IV therapy, and weekly visits thereafter
Duration: Up to 12 weeks
Study description at National Institutes of Health
Judith M. Martin, MD
For information, or to enroll, please contact:
Noreen Jeffrey, RN
Diane Gwin RN, MSN, CCRC
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One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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