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The objectives of this study are: 1) to conduct genome-wide studies of DNA methylation or gene expression and asthma in two tissues relevant to airway diseases: nasal epithelium and white blood cells, and 2) to study whether selected environmental exposures affect the methylation and gene expression signals identified in objective 1.
Between 2013 and 2017, approximately 500 Puerto Rican children ages 6 to 14 years, with and without asthma, were enrolled in the study.
Study visits took place at the Medical Science Campus of the University of Puerto Rico in San Juan. Study procedures included questionnaires, respiratory testing, and collection of nasal epithelial and blood samples.
National Heart, Lung, and Blood Institute University of Pittsburgh University of Puerto Rico
Pediatric Asthma Center at Children’s Hospital of Pittsburgh of UMPC Facts About Asthma Pulmonary Medicine, Allergy and Immunology Research
At Children’s Hospital of Pittsburgh of UPMC Juan C. Celedón, MD, DrPH
At the University of Puerto Rico Glorisa Canino, PhD
For more information about the study or enrollment, please contact:
At Children’s Hospital of Pittsburgh of UPMC Liz Hartigan, Research Coordinator 412-692-7060
At the Medical Science Campus of the University of Puerto Rico Sonia Delgado, Study Coordinator, or Edna Acosta-Perez, Co-Investigator 787-758-2525, Ext. 2129
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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