Asthma and Epigenetic Variation in Puerto Rican Children: The EVA-PR Study

Epigenetic Variation and Childhood Asthma in Puerto Ricans (EVA-PR)

Protocol Description

The objectives of this study are: 1) to conduct genome-wide studies of DNA methylation or gene expression and asthma in two tissues relevant to airway diseases: nasal epithelium and white blood cells, and 2) to study whether selected environmental exposures affect the methylation and gene expression signals identified in objective 1.

Eligibility Criteria

Between 2013 and 2017, approximately 500 Puerto Rican children ages 6 to 14 years, with and without asthma, were enrolled in the study.

Requirements

Study visits took place at the Medical Science Campus of the University of Puerto Rico in San Juan. Study procedures included questionnaires, respiratory testing, and collection of nasal epithelial and blood samples.

Status: Enrollment period ended. Data analysis ongoing.

Source(s) of Support

National Heart, Lung, and Blood Institute
University of Pittsburgh
University of Puerto Rico

Primary Investigator

At Children’s Hospital of Pittsburgh of UPMC
Juan C. Celedón, MD, DrPH

At the University of Puerto Rico
Glorisa Canino, PhD

Contact Information

For more information about the study or enrollment, please contact:

At Children’s Hospital of Pittsburgh of UPMC
Liz Hartigan, Research Coordinator
412-692-7060

At the Medical Science Campus of the University of Puerto Rico
Sonia Delgado, Study Coordinator, or Edna Acosta-Perez, Co-Investigator
787-758-2525, Ext. 2129