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Carriers of premutation (CGG) expansions of the Fragile X gene are generally thought to be spared most of the problems associated with the full mutation. However, a newly identified neurological disorder, involving progressively severe tremor and difficulty with walking and balance, appears to specifically affect some older premutation carriers, generally grandfathers of children with Fragile X Syndrome. Although this neurological disorder occurs by a completely separate mechanism from Fragile X Syndrome – and affects different individuals – it is caused by the same gene and, therefore, opens a new portal for understanding how the Fragile X gene works.
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Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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Interested in giving to Children's Hospital? Support the hospital by making a donation online, joining our Heroes in Healing monthly donor program, or visiting our site to learn about the other ways you can give back.