The Brain Regulation of Emotions and Thoughts (BREATHE)

Protocol Description

The Brain Regulation of Emotions and Thoughts (BREATHE) research study is actively recruiting children and adolescents ages 10-15 years old who have a parent or sibling diagnosed with bipolar disorder.

Eligibility Criteria

  • Young People 10-15 ages
  • Daily access to smart phone or tablet
  • Young person who has a parent or sibling who has been diagnosed with bipolar disorder
  • Young person has not been diagnosed with bipolar disorder, schizophrenia, or autism spectrum disorder


BREATHE participants also have the option of participating in BREATHE-Smart.

BREATHE: Participation involves 2 study visits. During a 1-2 hour baseline visit, the participant will be asked to answer questions and the researchers will confirm that a parent or sibling has a diagnosis of bipolar disorder. The participant will also be asked to come back for a 2-3 hour study visit to undergo a functional Magnetic Resonance Imaging (fMRI) scan, an imaging technique for measuring brain function. fMRI is non-invasive and does not involve radiation.

BREATHE-Smart: Participation involves psychiatric assessments, questionnaires, and MRI brain scans. Participants will also be asked to use the "Smiling Mind" mindfulness app for at least five minutes per day for four weeks and to take part in a video chat. After the use of the app for four weeks, participants will be asked to have an additional MRI. During a two-month follow-up appointment, the participant and their parent will complete additional questionnaires.

Status: Open to Enrollment

Additional Information

Adolescent Medicine Research


  • BREATHE: $240
  • BREATHE-Smart: up to $497

Primary Investigator

Danella Hafeman, MD

Contact Information