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The purpose of this research study is to evaluate ways to find kidney disease early in adult congenital heart disease (ACHD) patients. A healthy kidney should be able to increase its filtration fraction in response to a stimulator such as a high dose of protein. This ability is called “kidney reserve.” A lack of renal fitness may indicate a poor ability of the kidney to respond to external stressors. Researchers hope to determine if ACHD patients have kidney reserve and, if so, the levels of urine proteins can be used to predict future kidney injury.
The study is enrolling males and females, ages 18 to 40, with a history of congenital heart disease and plans for surgery in the near future.
Males and Females: Ages 18 to 40
For Part 1 of the study, participants will visit the Pediatric Clinical and Translational Research Center of UPMC Children’s Hospital of Pittsburgh in advance of their surgery for an examination and to provide blood and urine samples. Part 2 occurs when participants are admitted to the hospital for surgery, at which time researchers will monitor blood creatinine levels and urine production until the patient leaves.
Visits: 1 to 3
Duration: Dependent on surgery scheduling and ends with Part 2
National Institutes of Health
Adult Congenital Heart Disease Center
Congenital Heart Defect Types
Dana Fuhrman, DO, MS
For more information about the study, please contact:
Morgan Hindes, Research Coordinator
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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