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This multi-center study evaluates the effects of methylprednisolone in infants undergoing cardiopulmonary bypass surgery with a goal of determining the optimal dosing level. Methylprednisolone is an anti-inflammatory steroid. Researchers believe that it may help decrease post-operative inflammation and, in so doing, decrease a child’s risk of serious complications including liver, kidney, or respiratory failure.
Subject to certain exclusion criteria, infants up to 12 months of age who were born with a heart defect that requires surgery with cardiopulmonary bypass are eligible to participate.
Boys and Girls: Up to 12 months of age
Participants will be randomly assigned to receive either the study drug or a placebo at the time of surgery. . After the surgery is completed, each participant will undergo routine post-operative care, with researchers monitoring and recording details about his or her recovery.
Visits: None beyond standard care
Duration: Same as standard care for the surgical procedure
National Institutes of Health
Study Description at National Institutes of Health
Brian Blasiole, MD, PhD
For more information about the study or enrollment, please contact:
Denise McCarthy RN, BSN, CRC
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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