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This multi-center study evaluates the effectiveness of sugammadex following a surgical procedure to reverse the effects of a muscle relaxant used during surgery. Researchers believe that sugammadex, also known by the trade name Bridion™, may be superior to the conventional drug used to reverse moderate neuromuscular blocking as measured by time to neuromuscular recovery.
Subject to certain exclusion criteria, children newborn through ages 2 who require a neuromuscular blocking agent for a non-emergency surgical procedure are eligible for this study.
Boys and Girls: Up to Age 2
Participants will be given a muscle relaxant drug at the beginning of surgery and will receive sugammadex at a specified dosage at the end of the procedure. Blood testing will be done to evaluate how the body processes the study drug on some patients.
Visits: Requires hospitalization for surgery and a follow-up visit and phone call in the post-operative period
Duration: 28 days
Merck Sharp & Dohme
Study Description at National Institutes of Health
Daniela Damian, MD
For more information about the study or enrollment, please contact:
Denise McCarthy RN, BSN, CRC
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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