COVID-19 Vaccine Information and Updates
Read the Latest
Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Ranked #9 Nationally by U.S. News & World Report.
This study evaluates the safety and effectiveness of administering high-dose chemotherapy followed by infusion of the patient’s own CD34-selected peripheral blood stem cells (PBSC) in pediatric and young adult patients with severe Crohn's disease. Crohn's disease may be caused or aggravated by the individual's own immune system. The goal of the study is to try to reset the immune system. The chemotherapy is intended to remove or reduce the patient’s immune cells so they can be replaced with CD34 stem cells, which researchers believe will mature into immune cells that will not cause the inflammation associated with Crohn's disease.
Subject to certain exclusion criteria, the study is accepting participants of both genders between the ages of 5 and 60 who have been diagnosed with severe Crohn’s disease.
Males: 5 to 60 years old
Females: 5 to 60 years old
This study requires several weeks of hospitalization. Prior to transplant, stem cells will be harvested from the patient’s peripheral blood (PBSC). A regimen of chemotherapy will be provided within the hospital setting. Following that, patients will receive, via infusion, a transplant of their own CD34-selected PBSCs.
Visits: Requires hospitalization for several weeks of conditioning prior to transplant
Duration: 5 years for follow up
Miltenyi Biotec GmbH
Study Description from the National Institutes of Health
Paul Szabolcs, MD
For information about the study or enrollment, please contact:
Shawna McIntyre, Clinical Research Supervisor
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Support the hospital by making a donation online, joining our Heroes in Healing monthly donor program, or visiting our site to learn about the other ways you can give back.