Respiratory Tract Infection Identification in HSCT Patients

Pathogen Identification in Pediatric Hematopoietic Stem Cell Transplant Patients with Suspected Lower Respiratory Tract Infection

Protocol Description

This research initiative of the Pediatric Blood and Marrow Transplant Consortium evaluates next-generation genetic sequencing techniques to identify potential sources of lung infection in respiratory secretions of patients who have had hematopoietic stem cell transplant (HSCT). Sources of infection may include bacteria, viruses, fungi, and other organisms.

Eligibility Criteria

Subject to certain exclusion criteria, this study is enrolling patients who have a history of HSCT and are planned to undergo a clinically indicated collection of a lower respiratory specimen due to a suspected lung infection or inflammation.
Males and Females: Up to 21 years of age


Respiratory secretions will be collected from the lower lung via bronchoalveolar lavage, tracheal aspirate, or other means. Other sampling – nasal swab, urine, and blood sample – may also be done.
Visits: None beyond normal clinical care for this condition
Duration: Not applicable

Status: Open to Enrollment

Source(s) of Support

Pediatric Blood and Marrow Transplant Consortium (PBMTC SUP1601)

Primary Investigator

Jessie Barnum, MD

Contact Information

For more information about the study or enrollment, please contact:
Shawna McIntyre, Clinical Research Supervisor