Read the Latest
Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Ranked #6 Nationally by U.S. News & World Report.
This research study evaluates the effectiveness of combined lung and bone marrow transplant (BMT) procedures for treatment of an end-stage lung disease, which can include, but is not limited to, emphysema, idiopathic pulmonary fibrosis, and chronic obstructive pulmonary disease, along with bone marrow failure. Researchers believe that a lung transplant first will allow restoration of pulmonary function, which would enable patients to proceed to BMT to restore hematologic function.
Subject to certain exclusion criteria, this study is enrolling participants, ages 18 to 60, who have end-stage lung disease and meet criteria for lung transplantation, and who have evidence of bone marrow failure.
Males and Females: Ages 18-60
Participants will receive a double lung transplant from a partial human leukocyte antigen-matched deceased organ donor with an identical blood type. Preparation for BMT may start 8 weeks after lung transplant. Participants will receive a reduced intensity BMT procedure, with the graft cells purged of T and B lymphocytes prior to transplantation via venous infusion. Patients will be followed for up to 2 years following transplant procedures.
Visits: 11 follow-up visits after the transplant procedures
Duration: At least 26 months
University of Pittsburgh Medical Center
Study Description at the National Institutes of Health
Blood and Marrow Transplantation and Cellular Therapies Research
Paul Szabolcs, MD
For more information about the study or enrollment, please contact:
Shawna McIntyre, Clinical Research Supervisor
*Original research initiated by investigators at UPMC Children’s Hospital of Pittsburgh.
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Support the hospital by making a donation online, joining our Heroes in Healing monthly donor program, or visiting our site to learn about the other ways you can give back.