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This is a large-scale multi-center study of personalized, targeted immune modulation in children with sepsis-induced multiple organ dysfunction syndrome (MODS) in the PICU. The study includes two concurrent, immunophenotype-driven placebo controlled RCTs that will address the central hypothesis that individualized, pathophysiology-specific immunomodulation will improve outcomes from sepsis-induced MODS in children. Children’s Hospital of Pittsburgh of UPMC is part of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)'s Collaborative Pediatric Critical Care Research Network (CPCCRN) involving 26 U.S. hospitals and up to 1000 child participants.
Critically ill children admitted to the PICU from newborn age up to 17 years may take part in this research study if they meet eligibility requirements. Among those requirements, participants must have sepsis-induced MODS.
Boys: Newborn to 17 years
Girls: Newborn to 17 years
While in the PICU, children will be tested for immune phenotypes which determines whether the child will receive a test intervention or placebo or no intervention.
Visits: Occurs during hospitalization
Duration: Up to 1 year
National Institute of Child Health and Human Development
Study Description at National Institutes of Health (GRACE-2)
Study Description at National Institutes of Health (TRIPS)
Joseph A. Carcillo, MD (Site Primary Investigator)
Ericka L. Fink, MD (Site Co-Investigator)
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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