Blood Clotting in Traumatic Injury

Mechanism of Trauma-Induced Coagulopathy in Pediatric Patients

Protocol Description

The purpose of this study is to help researchers understand processes that prevent blood from clotting normally for some severely injured children. This condition, known as trauma-induced coagulopathy or TIC, is an abnormal response to injury. TIC can increase risks for both bleeding and clotting and is associated with poor outcomes, including death, disability, and blood clots. By better understanding the mechanisms behind TIC, researchers hope to identify ways to improve the care provided to seriously injured children.

Eligibility Criteria

Patients of both genders, through age 17, who were admitted to the trauma bay at UPMC Children’s Hospital of Pittsburgh after a serious injury, will be eligible to participate in this study.
Males and Females: Up through 17 years of age


When routine blood draws are taken upon arrival at the hospital and upon admittance to the Intensive Care Unit, additional small blood samples will be collected for research purposes. Researchers will also obtain medical record information for each participant.
Visits: 1
Duration: Not applicable

Status: Open to Enrollment

Additional Information

Emergency Medicine Research

Primary Investigator

Christine Leeper, MD

Contact Information

For more information about the study, please contact:
Research Coordinator