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Through this multi-center study, researchers are investigating whether microRNA and cytokines that may be present in the saliva can be used as tests to predict severe COVID-19 disease in children. If found to be useful, using saliva samples to predict severity of disease will be a painless way of testing children for severe COVID-19 disease. This study is part of a group of National Institutes of Health research grants to develop approaches for identifying children at high risk for multisystem inflammatory syndrome in children (MIS-C), a rare and severe after-effect of COVID-19 or exposure to the virus that causes it.
The study recruits from pediatric patients seen in the Emergency Department of UPMC Children’s Hospital of Pittsburgh who present with symptoms that necessitate a test for SARS-CoV2.
Boys and Girls: Up to age 18
During the Emergency Department visit, saliva samples will be collected from participants using a cheek swab. Additionally, participants or their parent/guardians will be asked to complete a survey about how the family is coping with the pandemic. Medical record information about participants will also be collected. Researchers will follow up with families by telephone 7 and 30 days after the participant is discharged from the hospital.
Visits: 1, the initial Emergency Department visit, plus telephone follow up
Duration: 30 days
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institutes of Health
COVID-19: What is it?
Emergency Medicine Research
Srinivasan Suresh MD
For more information about the study or enrollment, please contact:
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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