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Through this multi-center study, researchers are investigating whether microRNA and cytokines that may be present in the saliva can be used as tests to predict severe COVID-19 disease in children. If found to be useful, using saliva samples to predict severity of disease will be a painless way of testing children for severe COVID-19 disease. This study is part of a group of National Institutes of Health research grants to develop approaches for identifying children at high risk for multisystem inflammatory syndrome in children (MIS-C), a rare and severe after-effect of COVID-19 or exposure to the virus that causes it.
The study recruits from pediatric patients seen in the Emergency Department of UPMC Children’s Hospital of Pittsburgh who present with symptoms that necessitate a test for SARS-CoV2. Boys and Girls: Up to age 18
During the Emergency Department visit, saliva samples will be collected from participants using a cheek swab. Additionally, participants or their parent/guardians will be asked to complete a survey about how the family is coping with the pandemic. Medical record information about participants will also be collected. Researchers will follow up with families by telephone 7 and 30 days after the participant is discharged from the hospital. Visits: 1, the initial Emergency Department visit, plus telephone follow up Duration: 30 days
Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health
COVID-19: What is it? Emergency Medicine Research
Srinivasan Suresh MD
For more information about the study or enrollment, please contact: Research Coordinator 412-692-8380
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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