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The purpose of the research study is to evaluate whether giving certain medications daily can help decrease the amount of time that a child has Lyme arthritis joint swelling and pain. Lyme arthritis results from Lyme disease, which is caused by an infection after a tick bite. Although Lyme arthritis usually resolves with antibiotic treatment for most patients, some continue to have joint swelling. Researchers believe that prescribing a nonsteroidal anti-inflammatory drug (NSAID) on a scheduled basis at the time of diagnosis of Lyme arthritis may prevent excessive inflammation and decrease the number of patients with persistant Lyme arthritis, or at least decrease the duration of Lyme arthritis symptoms.
Subject to certain exclusion criteria, pediatric patients treated by the Emergency Department for joint swelling due to arthritis, who are also being tested for Lyme disease, will be invited to participate in the research study.
Boys and Girls: Ages 3 through 17
In addition to being prescribed an antibiotic for treatment of Lyme disease, participants will be randomly assigned to take either an analgesic pain medicine (acetaminophen), an NSAID (naproxen), a sequence of both, or neither for up to 28 days. Using a text survey, the research team will follow up with participants 8 times in the first month, then monthly until symptoms are completely gone.
Visits: 1, the initial Emergency Department visit
Duration: About 60 days
Study Description at National Institutes of Health
Emergency Medicine Research
Desiree Noel Wagner Neville, MD
For more information about the study or enrollment, please contact:
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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