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The purpose of this multi-center research study is to determine if one type of intravenous (IV) fluid is better than another at protecting kidney function in treatment of pediatric patients with sepsis, a severe inflammatory response to an infection that can impair the normal function of certain organ systems. Both solutions used in this study are approved by the U.S. Food and Drug Administration and are recommended as part of standard care for sepsis, restoring fluid balance to improve blood pressure and lower heart rate.
Subject to certain exclusion criteria, pediatric patients seen by the Emergency Department who will require hospitalization for their sepsis will be invited to participate in the research study. Boys and Girls: Ages 6 months through 17 years
Participants will be randomly assigned to be given either normal saline or lactated Ringer’s solution for treatment of sepsis disease for up to 48 hours after the initial Emergency Department visit. After that time, if IV fluids are still required, the patient’s doctor will determine which IV fluid is used. For analytical purposes, researchers will use blood samples collected at the time of enrollment, after the study-fluid period is complete and before the patient leaves the hospital or 28 days after enrollment, whichever comes first. Visits: 1, the initial Emergency Department visit Duration: Up to 28 days
Study Description at National Institutes of Health Sepsis (Septic Shock) Emergency Medicine Research
Robert Hickey, MD
For more information about the study or enrollment, please contact: Dr. Hickey 412-864-8380
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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