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The goal of this multi-center research study is to determine the effectiveness of the oral antibiotic azithromycin in treating preschoolers experiencing acute wheezing episodes.
Children, ages 18 through 59 months, being seen in the Emergency Department for an acute wheezing episode, are eligible for participation in this study.
Boys and Girls: Ages 18 months through 4 years (59 months)
Participants will be given a physical examination that will include a cheek and nasal swab to collect biologic samples. Through randomized selection, participants will be provided a 5-day prescription of either azithromycin or a placebo. Parents/guardians will provide information about the child’s symptoms during the Emergency Department visit and will complete a daily diary about the child’s symptoms during drug therapy. The research team will follow up with the parent/guardian on day 8. Some children will be randomly selected for follow-up visits for additional examinations and testing.
Visits: 1 to 3, depending on whether participating in follow-up visits
Duration: 8 to 21 days, depending on whether participating in follow-up visits
National Heart, Lung, and Blood Institute
Study Description at National Institutes of Health
Asthma and Wheezing
Emergency Medicine Research
Melissa Tavarez, MD
For more information about the study or enrollment, please contact:
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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