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Below is a partial list of published papers related to this research study.
A C. elegans model of human α1-antitrypsin deficiency links RNAi to misfolded protein turnover OS Long, JA Benson, JH Kwak, CJ Luke, SJ Gosai, LP O'Reilly, Y Wang, J Li, AC Vetica, MT Miedel, DB Stolz, SC Watkins, S Züchner, DH Perlmutter, GA Silverman, SC Pak Human Molecular Genetics 2014 Oct 16
A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency LP O'Reilly, OS. Long, MC Cobanoglu, JA Benson, CJ Luke, MT Miedel, P Hale, DH Perlmutter, I Bahar, GA Silverman, SC Pak Human Molecular Genetics 2014 Oct 16
C. elegans in high-throughput drug discovery LP O'Reilly, CJ Luke, DH Perlmutter, GA Silverman, SC Pak Advanced Drug Delivery Reviews 2014 April
Fluphenazine reduces protetotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency (PDF) J Li, SC Pak, LP O’Reilly, JA Benson, Y Wang, T Hidvegi, P Hale, C Dippold, M Ewing, GA Silverman, DH Perlmutter PLOS ONE 2014 Jan 31
Mysteries of α1-antitrypsin deficiency: Emerging therapeutic strategies for a challenging disease R Ghouse, AS Chu, Y Wang, DH Perlmutter Disease Models & Mechanisms 2014
Capitalizing on the autophagic response for treatment of liver disease caused by alpha-1-antitrypsin deficiency and other genetic diseases AS Chu, DH Perlmutter, Y Wang BioMed Research International 2014
Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways LP O'Reilly, JA Benson, EE Cummings, DH Perlmutter, GA Silverman, SC Pak Expert Opinion Drug Discoveries 2014
Targeting intracellular degradation pathways for treatment of childhood liver disease due to α1-antitrypsin deficiency (PDF) Y Wang, DH Perlmutter Pediatric Research 2013 Dec 11
Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin (PDF) SJ Gosai, JH Kwak, CJ Luke, OS Long, DE King, KJ Kovatch, PA Johnston, TY Shun, JS Lazo, DH Perlmutter, GA Silverman, SC Pak PLOS ONE 2010 Nov 12
An autophagy-enhancing drug promotes degradation of mutant α-antitrypsin Z and reduces hepatic fibrosis T Hidvegi, M Ewing, P Hale, C Dippold, C Beckett, C Kemp, N Maurice, A Mukherjee, C Goldbach, S Watkins, G Michalopoulos, DH Perlmutter Science 2010 Jul 9
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