COVID-19: Safety, Testing, News Alerts, and More.
Read the Latest Update
Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Ranked #9 Nationally by U.S. News & World Report.
This long-term observational study is being done to learn more about four liver diseases in which the flow of bile is poor, a condition known as cholestasis. Cholestatic liver diseases in children and young adults are serious, and not enough is known about their causes or long-term effects. The diseases being studied include Alagille syndrome (AGS), Alpha-1-antitrypsin deficiency (Alpha-1 or ATD), progressive familial intrahepatic cholestasis (PFIC) and bile acid synthesis defects. Through this study, the Childhood Liver Disease Research Network (ChiLDReN) will collect and share medical data from participants to help researchers better understand the causes and effects of the diseases over time. The study will take place at UPMC Children’s Hospital of Pittsburgh through the University of Pittsburgh.
Subject to certain exclusion criteria, the study is open to individuals of both genders, from birth through age 25, who have been diagnosed with one of the four diseases being studied.
Males and Females: Birth through age 25
Medical record information and blood and urine samples will be collected for each participant. Sample collection for research purposes will be planned whenever possible to occur at the same time it is being done for routine clinical tests. Biological parents will also be asked to participate by providing family history and blood or saliva samples for DNA analysis.
Visits: 1 per year
Duration: Up to 20 years
National Institute of Diabetes and Digestive and Kidney Diseases
Study Description at National Institutes of Health
Childhood Liver Disease Research Network
Patrick McKiernan, MD
For more information about this study or enrollment, please contact:
Kathryn Bukauskas, RN, CCRC
Amanda Blasko, RN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Support the hospital by making a donation online, joining our Heroes in Healing monthly donor program, or visiting our site to learn about the other ways you can give back.