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The primary purpose of this multi-center research program is to study the safety of various vaccine combinations and determine which provide the greatest protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and variants that cause COVID-19.
Subject to certain exclusion criteria, this study is enrolling participants, ages 18 and older, who were fully vaccinated using one of the three vaccinations approved in the U.S. under the Food and Drug Administration’s emergency use authorization (EUA): the Moderna, Pfizer/BioNTech, and Janssen Pharmaceuticals/Johnson & Johnson vaccines. A second group in this study will include adults who have not previously received the vaccination.
Males and Females: Ages 18 and older
Participants in the first study group will be given a single dose of a COVID vaccine within 12 to 20 weeks after they received the last dose of their EUA vaccine. The second study group will receive the 2-dose Moderna vaccine and will receive a booster 12 to 20 weeks after their second injection. All participants in the study will be followed for 12 months after receiving their vaccine boost and will provide blood samples that researchers will use to study their immune response against the new variants of COVID-19.
Visits: About 6 for Group 1 and about 9 for Group 2
Duration: About a year
National Institute of Allergy and Infectious Diseases
Study Description at National Institutes of Health
COVID-19: What is it?
COVID-19 Vaccine, Moderna
General Academic Pediatrics Research
Judith Martin, MD
For more information about the study or enrollment, please contact:
The Pittsburgh Vaccine Trials Unit
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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