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The National Institutes of Health-funded D3VH research study will help researchers understand whether increasing the vitamin D levels of vitamin D-deficient children with obesity can improve their heart-health. Obese and overweight children have a higher chance of having cardiovascular disease risk factors and vitamin D deficiency, which itself is a cardiovascular risk factor. Childhood heart-health risk factors can track into adulthood. Potentially, improvement of cardiovascular health of obese and overweight children through vitamin D supplementation may reduce their risk of heart disease later in life.
Subject to certain exclusion criteria, the D3VH study is enrolling healthy 10- to 18-year-old obese and overweight children (body mass index in 85th percentile or higher), who are found to be vitamin D-deficient in the screening evaluation.
Boys and Girls: Ages 10 to 18
Eligible participants will have 3 study visits over 6 months at the Clinical and Translational Research Center at the Montefiore Hospital of UPMC in Oakland. Enrolled children will be randomly assigned to take one of 3 dose levels of vitamin D3 in tablet form (600 IU or 1000 IU or 2000 IU) once a day for 6 months. Study procedures will include vascular function testing, body composition assessment, blood tests, and questionnaires.
Duration: 6 months
National Heart, Lung, and Blood Institute (NHLBI)
Study Description at National Institutes of Health
Kumaravel Rajakumar, MD, MS
For more information about the study or enrollment, please contact:
or Study Coordinator Flora Olabopo, BS
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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