Your health can’t wait. Learn how we’re making our facilities safer and schedule your care now.
Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Ranked #9 Nationally by U.S. News & World Report.
Through this Pediatric Brain Tumor Consortium investigation, researchers are studying the effects of pembrolizumab (MK-3475) in treating young patients with progressive, recurrent, or refractory high-grade gliomas, brain stem tumors (diffuse intrinsic pontine glioma, or DIPG), ependymoma, medulloblastoma, or brain tumors with a high number of genetic mutations. Researchers believe that immunotherapy with monoclonal antibodies, such as MK-3475, may induce changes in the body's immune system that may interfere with the ability of tumor cells to grow and spread.
Subject to certain exclusion criteria, this study is enrolling pediatric patients who have a progressive, recurrent, or refractory high-grade glioma, DIPG, enendymoma, medulloblastoma, or hypermutated brain tumors.
Males and Females: Ages 3 to 21
Participants will receive an intravenous infusion of MK-3475 on the first day of a 21-day cycle that repeats for 34 cycles, in the absence of disease progression or unacceptable toxicity. Physical examinations will be given prior to infusions, and more frequently during the participants’ first cycles of the study. Imaging, blood work, and other tests will be done at prescribed intervals.
Visits: About 42
Duration: Approximately 2 years
National Cancer Institute
Pediatric Brain Tumor Consortium (PBTC-045)
Study Description at the National Institutes of Health
Cancer and Blood Disorder Research
Alberto Broniscer, MD
For more information about the study or enrollment, please contact:
Research Coordinator Sharon Dibridge
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Support the hospital by making a donation online, joining our Heroes in Healing monthly donor program, or visiting our site to learn about the other ways you can give back.