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Through this Pediatric Brain Tumor Consortium investigation, researchers are studying the effects of pembrolizumab (MK-3475) in treating young patients with progressive, recurrent, or refractory high-grade gliomas, brain stem tumors (diffuse intrinsic pontine glioma, or DIPG), ependymoma, medulloblastoma, or brain tumors with a high number of genetic mutations. Researchers believe that immunotherapy with monoclonal antibodies, such as MK-3475, may induce changes in the body's immune system that may interfere with the ability of tumor cells to grow and spread.
Subject to certain exclusion criteria, this study is enrolling pediatric patients who have a progressive, recurrent, or refractory high-grade glioma, DIPG, enendymoma, medulloblastoma, or hypermutated brain tumors.
Males and Females: Ages 3 to 21
Participants will receive an intravenous infusion of MK-3475 on the first day of a 21-day cycle that repeats for 34 cycles, in the absence of disease progression or unacceptable toxicity. Physical examinations will be given prior to infusions, and more frequently during the participants’ first cycles of the study. Imaging, blood work, and other tests will be done at prescribed intervals.
Visits: About 42
Duration: Approximately 2 years
National Cancer Institute
Pediatric Brain Tumor Consortium (PBTC-045)
Study Description at the National Institutes of Health
Cancer and Blood Disorder Research
James Felker, MD
For more information about the study or enrollment, please contact:
Research Coordinator Sharon Dibridge
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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