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This multi-center Children’s Oncology Group study investigates the best approach to combine chemotherapy and radiation therapy based on the patient's response to induction chemotherapy in young people with non-germinomatous germ cell tumors (NGGCT).
Subject to certain exclusion criteria, this study is enrolling patients ages 3 through 29 years diagnosed with NGGCT.
Males and Females: Ages 3 through 29 years
Participants will receive up to 6 cycles of induction chemotherapy, each lasting 3 weeks, after which a determination will be made as to whether surgical removal of the tumor is required. Following evaluation, study participants will also be assigned to one of two plan protocols. Plan A requires radiation therapy 5 days a week for about 6 weeks, with radiation to the spine and only a portion of the brain. Plan B consists of consolidation chemotherapy, peripheral blood stem cell rescue and radiation therapy involving the whole brain and spine.
Visits: Number of visits will vary based on study arm and the participant’s response to protocol.
Duration: For most, about 6 to 11 months, depending on which treatment plan is applied.
Children’s Oncology Group (ACNS2021)
National Cancer Institute
Study Description at the National Institutes of Health
Cancer and Blood Disorder Research
James Felker, MD
For more information about the study or enrollment, please contact the UPMC Children’s Hospital of Pittsburgh Neuro-Oncology team, at:
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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